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临床试验/NCT02012738
NCT02012738已完成不适用

MemoTV: Epigenetic, Neural and Cognitive Memories of Traumatic Stress and Violence in Former Offenders of the Townships of South Africa

University of Konstanz1 个研究点 分布在 1 个国家目标入组 45 人开始时间: 2013年10月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
45
试验地点
1
主要终点
Change in PTSD symptom severity with the PSS-I the Post-traumatic Stress Disorder Scale- Interview (PSS-I) post-treatment at 6- and 12-month follow-up

研究概览

简要总结

Escalating violence is omnipresent in South African townships and can be traced back to two core mechanisms: a trauma-related hyper-arousal and a positive rewarding perception of violence. In the past, there was no therapeutic intervention available addressing both, trauma and the so-called appetitive aggression. The University of Konstanz has developed a culturally sensitive and scientifically based short-term intervention for the treatment of traumatized patients, the Narrative Exposure Therapy (NET), that has proven its effectiveness in various randomized clinical studies in different war-affected populations. Recently, the NET has been adapted for the forensic offender rehabilitation (FORNET) by also addressing the perpetration of violence related to a self-rewarding perception of the exposure with violence. It has shown to be effective in reducing the number of committed offenses in a perpetrator sample in Burundi and to reduce PTSD symptoms in a perpetrator sample in the Democratic Republic of the Congo. In this study, we investigated the therapeutic efficiency of FORNET in a randomized clinical control trial with a sample of former offenders of the townships of Cape Town. In addition to the previous studies, we specifically addressed the context of ongoing stress and linked our findings to epigenetic markers of stress and violence. Participants were followed over a period of up to 25-months post-treatment. The FORNET was also disseminated to local staff of our collaboration partners from the South African Universities and an organization working in the townships to warrant sustainability of the therapeutic intervention.

详细描述

A group of 290 former young male offenders and young males at risk for perpetrating or becoming victims of crime (age 10-40) from Cape Town, recruited via a community based skill-training program has been interviewed in a first step. Participants with neurological or psychiatric disorders other than those resulting from exposure to traumatic stress, like chronic psychosis, were excluded from participation in the study but received referrals in the professional health care system, if necessary.

We applied standardised clinical questionnaires in a semi-structured interview for the assessment of exposure to traumatic stress (Children Exposed to Community Violence (CEVC)), trauma symptomatology (PSS-I for diagnosis of post-traumatic stress disorder), aggression (Appetitive Aggression Scale (AAS); Buss & Perry Aggression Questionnaire), offense types checklist (from the AAS) and related drug abuse, psychosocial functioning (Work and Social Adjustment Scale, WSAS) and suicidality (M.I.N.I. 6.0.0., shortened version). Additionally, we used a questionnaire about social acknowledgement (Social Acknowledgement Questionnaire) and substance dependence (M.I.N.I. version 6.0.0).

We set up a randomised clinical intervention trial for the treatment of former offenders that covers violence perpetration on the one hand and traumatization on the other. 90 participants were chosen by the highest aggression scale scores and a certain threshold of trauma symptoms. 17 participants received FORNET, while 14 matched participants received CBT and another 7 matched participants treatment as usual (Waiting List camp) in a camp. Matching took place according to the severity of trauma symptomatology, aggressive behavior and suicidality. 36 participants didn't receive intervention and weren't part of the camp (Waiting List no camp) but were included in the follow-ups. In order to compare the treatment effect with the two control groups and follow the long-term effects, post-treatment assessments with the initial survey were performed about 8, 18 and 25 months post-treatment.

After the follow-ups, 17 FORNET participants and 11 CBT participants were included in the analysis. Two CBT clients had been excluded since they had not come to the follow-ups, one CBT client died a relatively sudden death due to a severe disease. The camp waiting list had been reduced to only six persons since one participant of the waiting list has been stabbed to death in a gang fight. Therefore a combined waiting list has been emerged from the two waiting lists ("camp" and "no camp"). 13 men from the "no camp"-waiting list were excluded since they have not been to the follow ups. From the residual 21 clients from this waiting list, 11 have been matched (together with the six participants from the "camp"-waiting list) with the participants from the FORNET and CBT group in terms of post traumatic stress symptom severity, level of appetitive aggression and suicidality. In the end 17 FORNET-, 11CBT- and 17 waiting list-attendees have been included into the analysis, hence a total sample size of 45 participants.

The 2 subjects of the control group, that still fulfilled the criteria for the therapy study and were interested in it, received FORNET by trained ZA staff for ethical reasons and to examine whether it is possible to effectively disseminate FORNET.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
10 Years 至 40 Years(Child, Adult)
性别
Male
接受健康志愿者
否

入选标准

  • •High levels of PTSD symptoms (i.e. Scores on the PSS-I > 7 points)
  • •High levels of appetitive aggression (i.e. Scores on the Appetitive Aggression Scale (AAS) > 8 points)
  • •participants are recruited through the community based re-integration program

排除标准

  • •acute psychotic episode

研究组 & 干预措施

Assignment to FORNET

Active Comparator

17 participants were randomly assigned to FORNET

干预措施: FORNET (Behavioral)

Assignment to CBT

Active Comparator

14 participants were randomly assigned to CBT

干预措施: CBT (Behavioral)

Waiting List Control Group (camp)

Other

7 participants were randomly assigned to the Waiting List Control Group (camp)

干预措施: Waiting List Control Group (camp) (Other)

Waiting List Control Group (no camp)

Other

36 participants were assigned to the Waiting List Control Group (no camp)

干预措施: Waiting List Control Group (no camp) (Other)

结局指标

主要结局

Change in PTSD symptom severity with the PSS-I the Post-traumatic Stress Disorder Scale- Interview (PSS-I) post-treatment at 6- and 12-month follow-up

时间窗: 8, 18 and 25- month follow-up

Change in Attraction to violence with the Appetitive Aggression Scale (AAS) post-treatment at 6- and 12-month follow-up

时间窗: 8, 18 and 25- month follow-up

Change in Self-committed violence with the AAS offense list

时间窗: 8, 18 and 25- month follow-up

Change in Methylation Pattern of the Glucocorticoid Receptor promoter region via saliva samples

时间窗: 8, 18 and 25- month follow-up

Influence of Social Acknowledgement with Social Acknowledgement Questionnaire (SAQ)

时间窗: 8, 18 and 25- month follow-up

Influence of drug abuse related to violence on number of offenses with the offense checklist (from the AAS)

时间窗: 8, 18 and 25- month follow-up

Change in Epigenetic Markers (methylation patterns) of violence in the androgen receptor promoter region via saliva samples

时间窗: 8, 18 and 25- month follow-up

次要结局

  • Change in Strength of suicidal ideation measured with the MINI 6.0.0.(8, 18 and 25- month follow-up)
  • Change in Psychosocial Functioning measured with the WSAS (Work and Social Adjustment Scale)(8, 18 and 25- month follow-up)
  • Change in Depression severity with the PHQ-9(8, 18 and 25- month follow-up)

研究者

发起方
University of Konstanz
申办方类型
Other
责任方
Principal Investigator
主要研究者

Prof. Dr. Thomas Elbert

Professor for Clinical Psychology and Behavioural Neuroscience

University of Konstanz

研究点 (1)

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