Evaluating the Short-Term Effects of 3 Days of Caloric Restriction/Intermittent Fasting Using the Plexus(R) Program on Anthropometrics, Metabolism, Markers of Cardiovascular Health in Overweight/Obese Men and Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Change in body weight
研究概览
简要总结
The purpose of this study is to document the efficacy of a 3 day intermittent fasting/caloric restriction (IF/CR) using the Plexus® 3 day reset program on body weight as well as regulatory parameters of metabolism and metabolic flexibility. This study will provide data on the acute efficacy regarding the program but also identify the potential underlying physiological mechanisms through which the dietary intervention may elicit improvements, and the participant experience of the program. Collectively, this will provide a window into the possible adaptations with a longer-term dietary intervention.
详细描述
According to the US Centers for Disease Control, more than 42% of adults are classified as obese, and approximately 74% of US adults are classified as overweight (body mass index of 25.0 to < 30 kg/m2) or obese (>30 kg/m2) (Ow/Ob). The costs on human health are profound, increasing the risk of heart disease, stroke, type 2 diabetes, and certain cancers, and ultimately increasing morbidity associated with these chronic diseases. Obesity and the negative sequelae inflict staggering economic costs, estimated at $147 billion, and that was in 2008. Therefore, understanding and developing interventions that can help address Ow/Ob can reduce the risk of chronic disease, reduce healthcare costs, and likely improve quality of life.
One such intervention has been through altering diet and/or physical activity. However, prior systematic review and meta-analysis suggests that when comparing diet alone vs. exercise alone, dietary interventions result in ~3-fold greater weight loss (11 vs 3 Δkg). While the additional benefits of exercise are not be discounted, engaging dietary approaches can be a highly effective way to promote weight loss. Caloric restriction (CR) has long been touted as an effective method of inducing weight loss, although there are also issues with adherence and maintenance with such an approach. This study is seeking to understand the acute metabolic changes with engaging in a 3-day caloric restriction, which would typically be part of an intermittent fasting dietary regimen.
Specific Aim 1. Document the efficacy of the 3 day IF/CR on inducing short term weight loss, the nature of the weight loss changes (body composition), changes in anthropometrics (waist and hip circumference), changes in resting metabolic rate and changes in metabolic flexibility (relative utilization of fats versus carbohydrates).
Specific Aim 2. Explore the physiological responses to the 3 day IF/CR with the Plexus 3 day reset program through analysis of blood plasma for levels of insulin, glucose, lipid profile (total cholesterol, high- and low-density cholesterol (HDL/LDL)), pro- and anti-inflammatory mediators (Tumor Necrosis Factor-alpha, TNFa and Cortisol, respectively), ketones, thyroid stimulating hormone (TSH), and hormones related to hunger and satiety and thus energy intake (protein YY (PYY), neuropeptide Y (NPY), Ghrelin, and Leptin).
Specific Aim 3. Ascertain any possible changes in clinically relevant parameters such as heart rate, heart rate variability (HRV), blood pressure (central and peripheral), and vascular stiffness (augmentation index, AIx).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overweight or obese (body mass index, BMI > 27.5 kg/m2)
- •Weight stable (± 4.4 lb) for > 6 months prior
- •25 to 65 years of age
- •Participants will be expected to be otherwise relatively healthy without uncontrolled chronic disease (e.g. cardiovascular, metabolic, or pulmonary) and 2 or fewer positive risk factors for cardiovascular disease (CVD) (e.g. high blood pressure, high cholesterol, etc) as described by the American College of Sports Medicine (ACSM)/American Heart Association (AHA) Criteria.
- •Cleared by Physician
排除标准
- •Subjects who present with more than 2 CVD risk factors (AHA/ACSM criteria) or have uncontrolled/overt cardiovascular, pulmonary, or metabolic disease (Diabetes Mellitus)
- •Not cleared by their physician.
- •Recent blood donation (<8 weeks)
- •Those who have cancer or are being treated for cancer.
- •Women who are currently pregnant, breastfeeding, attempting to conceive, or amenorrheic (not associated with menopause).
- •Anyone who presents with food allergies to coconuts, dairy, soy, stevia, or nuts will also be excluded.
- •Those with eating disorders should not partake in this study.
研究组 & 干预措施
Pre- post-dietary intervention
Single arm pre-post dietary intervention (caloric restriction)
干预措施: 3 day caloric restriction/metabolic reset (Dietary Supplement)
结局指标
主要结局
Change in body weight
时间窗: (days 0 and 4)
Change in total body weight
次要结局
- Change in substrate utilization((days 0 and 4))
- Change peripheral blood pressure((days 0 and 4))
- Change in central blood pressure((days 0 and 4))
- Changes in sleep health(Days 0 through 4)
- Change in total body water((days 0 and 4))
- Change in body fat (%)((days 0 and 4))
- Change in lean mass (kg)((days 0 and 4))
- Change in waist circumference((days 0 and 4))
- Change in hip circumference((days 0 and 4))
- Changes in waist to hip ratio((days 0 and 4))
- Change in resting metabolic rate((days 0 and 4))
- Change in augmentation index((days 0 and 4))
- Change in heart rate variability((days 0 and 4))
- Changes in blood lipid profile((days 0 and 4))
- Changes in blood glucose regulation((days 0 and 4))
- Changes in blood markers of inflammation((days 0 and 4))
- Changes in circulating regulators of metabolism((days 0 and 4))
- Changes in perceptual indicators(Days 0 through 4)
研究者
Stephen J. Ives
Associate Professor
Skidmore College