Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- detection of number of dilated capillaries by nailfold capillaroscopy
研究概览
简要总结
Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune. The most common causes of pediatric uveitis are idiopathic and juvenile idiopathic arthritis-associated uveitis. Uveitis morbidities in pediatric patients include cataract, glaucoma, and amblyopia. Pediatric uveitis may be accopanied by involvement of the ocular vasculature, such as retinal vasculitis. We hypothesize that there are differences in systemic microcirculation between pediatric uveitis patients and healthy pediatric controls.
详细描述
The systemic microcirculation will be investigated through nailfold capillaroscopic (NFC) assessment with noninfectious uveitis and healthy pediatric controls.
The NFC parameters are:
capillary density (number of capillaries per mm), dilated capillaries (apex of >20µm), avascular areas, the presence of microhemorrhages, and capillary morphology (normal, multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with uveitis < 18 years old
排除标准
- •infectious uveitis
- •age > 18 years old
结局指标
主要结局
detection of number of dilated capillaries by nailfold capillaroscopy
时间窗: 6 months
number of dilated capillaries (apex of \>20µm)
detection of other abnormalities as avascular areas, microhemorrhages, and abnormal capillary morphology
时间窗: 6 months
detection of multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries
capillary density by nailfold capillaroscopy
时间窗: 6 months
(number of capillaries per mm)
次要结局
- correlation of nailfold findings with uveitis activity(6 months)
研究者
Maha Sayed Ibrahim Abdelrahman
Principal invesigator
Assiut University