PACTR201103000279108已完成未知
Children with HIV in Africa - Pharmacokinetics and Adherence of Simple Antiretroviral Regimens
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 64
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 3 Month(s) 至 13 Year(s)（—）
- 性别
- All
入选标准
- •1) HIV infected infants aged 3 months to <12 months currently taking or about to start LPV/r syrup based first-line following WHO guidelines 2008 [7].
- •HIV infected children able to swallow paediatric LPV/r tablets and aged 4-13 years and <25Kg, currently taking or about to start LPV/r based second-line following WHO guidelines.
- •HIV infected infants aged 1 to 4 years currently taking or about to start LPV/r syrup based first-line
- •2. Carers, and children where appropriate, willing and able to give informed consent
排除标准
- •1. Who are expected to change weight bands (i.e. change dose) after enrolment and before PK day at week 8
- •2. With anaemia (haemoglobin <8.5g/dL), or liver enzymes grade 2 or higher.
- •3. With illnesses that could influence the pharmacokinetics of the antiretroviral (ARV) drugs at week 4 and week 8 e.g. severe diarrhoea, vomiting, renal or liver disease
- •4. On concomitant medications that are known to interact with the ARV drugs
研究者
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