NL-OMON54195招募中不适用
Immunophenotypic Profile of Peripheral Blood Mononuclear Cells and T cell Function in Sickle Cell Disease Patients. - Immunophenotypic profile of PBMCs and T cell function in SCD.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 12 至 64（—）
入选标准
- •Inclusion criteria SCD patients
- •To be eligible to participate in this study, a subject must meet all the
- •following criteria:
- •o Age 12 years or older
- •o High performance liquid chromatography (HPLC) confirmed diagnosis of
- •o Willing and able to provide written informed consent
- •o For children 12-16 years: additional written informed consent of
- •parent/caretaker
- •Inclusion criteria healthy volunteers
- •To be eligible to participate in this study, a subject must meet all the
- •following criteria:
- •o Age 18 years or older
- •o Willing and able to provide informed consent
- •o No self-reported medical issues that could interfere with immunity
- •o Originating (or parents originating) from region where SCD occurs
排除标准
- •Exclusion criteria SCD patients
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •o History of allogeneic SCT
- •o Participation in Amsterdam UMC SCT biobank because of planned allogeneic SCT
- •o History of chronic infection or autoimmune inflammatory disease
- •o Pregnancy, self-reported
- •o Vaso-occlusive disease in the preceding 4 weeks, self-reported
- •o Red blood cell transfusion in the preceding 3 months, self-reported
- •Exclusion criteria for healthy volunteers
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •o Carriership of sickle cell gene or other hemoglobinopathy, self-reported
- •o Chronic infection, self-reported
- •o Chronic auto-inflammatory disease, self-reported
- •o Use of chronic medication that affects the immune system, self-reported
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