Familial Analysis of Keratoconus Risk
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- proportion of diagnosed keratoconus
研究概览
简要总结
The principal objective of this study is to evaluate the frequency of KC inside family of patients with confirmed KC.
It's a familial, epidemiological, prospective, single-center study.
详细描述
Keratoconus is a common bilateral progressive corneal ectatic disease causing visual impairment by inducing irregular astigmatism and corneal opacities. This disorder typically begins during teenage years, progresses until the age of 30 to 40 years and, in severe forms, may need a corneal transplantation.
Currently, keratoconus has not known etiopathogenesis, and it is difficult to detect subclinical forms.
Several risk factors seem to be implied, environmental and genetic : the risk of keratoconus in case of familial history of keratoconus isn't well known at that time, but seems to be important to consider to promote screening and follow up of patient with a familial history of keratoconus (KC).
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patient carrier of keratoconus
- •more than 7 years
- •patient who didn't expressed opposition as for computerization and use of data concerning him
- •Family of case
- •to have a first degree family member (father, mother, brother, sister, child) carrier of keratoconus
- •more than 7 years
- •patient who didn't expressed opposition as for computerization and use of data concerning him
排除标准
- •ocular pathology or antecedent of modification of cornea (surgery, traumatism, ocular hypertension, keratitis) which could interfere with topographical analysis
- •wearing of rigid contact lens for 15 days before exams, or flexible lens for 5 days before exams
结局指标
主要结局
proportion of diagnosed keratoconus
时间窗: 1 day
次要结局
- Assesment of familial history on KC severity(1 day)
- Evaluation of KC severity(1 day)