ACTRN12618001179224已完成未知
Safety and efficacy study of colchicine prophylaxis in gout patients commencing urate lowering therapy
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 200
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •*Gout according to the 2015 American College of Rheumatology and European League Against Rheumatism criteria
- •Serum urate >0.36mmol/
- •*At least one self-reported gout flare in last 6 months
- •*Fulfilling American College of Rheumatology criteria for urate lowering therapy with allopurinol (gout with greater than or equal to 2 flares in a year, tophi, chronic kidney disease greater than or equal to stage 2 (eGFR<90mls/min/1.73m2), or past kidney stones)
- •*Agreeable to starting allopurinol
- •*Ability to give informed consent
- •*Ability to communicate via telephone
排除标准
- •*Contra-indication or previous intolerance to allopurinol
- •*Contra-indication or previous intolerance to colchicine
- •*Urate lowering therapy within 1 month of enrolment
- •*Stage 4 or 5 chronic kidney disease
- •*Concomitant azathioprine, cyclosporine, or other immunosuppression
- •*Unstable co-morbid health conditions (e.g stage 4 heart failure, recent myocardial infarction, advanced cancer)
- •*Unable to comply with study procedures
- •*Use of regular non steroidal anti inflammatory for other medical conditions.
研究者
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