NCT04329260Unknown不适用
Mutation of the LEPR Gene at Reunion Island: Involvement in Pediatric Obesity GRÉOL (Génétique Réunion Obésité LEPR)
Centre Hospitalier Universitaire de la Réunion0 个研究点目标入组 250 人开始时间: 2021年3月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 250
- 主要终点
- Proportion of the Δ6-8 deletion of the LEPR gene in paediatric population
研究概览
简要总结
The objective of this study is to estimate the proportion of the recurrent deletion Δ6-8 of the LEPR gene in the homozygous and heterozygous state in pediatric cases with severe and early ( before the age of 6) obesity (BMI ≥ IOTF-30) on Reunion Island.
详细描述
The study of the deletion Δ6-8 of the LEPR gene starts with a saliva sample using a swab in children aged between 3 to 18 years old.
The DNA from this sample will then be analyzed by the PCR technique. If the deletion of the LEPR gene is confirmed in the patient, his adult family members will also be screened using the same procedure.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient with early severe and non syndromic obesity (BMI> IOTC-30) (before 6 years old)
- •adult family members with deletion of LEPR gene
- •informed consent form signed by participants or parents
- •affiliation to social security scheme
排除标准
- •patient with syndromic obesity
- •patient Under guardianship or Under judicial protection
结局指标
主要结局
Proportion of the Δ6-8 deletion of the LEPR gene in paediatric population
时间窗: at inclusion
Presence of the deletion of the LEPR gene
次要结局
- Proportion of the Δ6-8 deletion of the LEPR gene in adult family members(6 months after inclusion of the paediatric population)
研究者
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