Eating Phenotypes for Childhood Obesity in the Context of Familial Obesity Risk
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 212
- 试验地点
- 2
- 主要终点
- Waist circumference (cm)
研究概览
简要总结
Using an integrated approach, this study examines multiple eating traits concurrently under states of hunger and satiety. It examines the impact of short-term appetite and intake regulation on longer-term energy intake control and weight development in a cohort of ethnically diverse normal-weight and obese boys and girls with different familial predispositions to obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 7 Years 至 9 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •7-9 years of age
- •Normal-weight or overweight/obese who are at low risk or high risk for obesity based on maternal BMI
- •Like most foods served during the study
- •Be regular breakfast eaters
排除标准
- •Have serious medical conditions known to affect food intake or body weight
- •Have any developmental, medical, or psychiatric conditions that might impact study compliance
- •Have a learning disability or poor reading ability/comprehension
- •Have visual or auditory impairment
- •Are taking medications associated with developmental, medical, or psychiatric disorders or medications known to affect appetite, food intake or body weight
- •Are underweight
- •Have food allergies related to the foods served in the study or are lactose intolerant
- •Do not regularly eat breakfast
- •Do not like or cannot eat foods served during experimental meal or are unable to finish compulsory preload
- •Mothers who are pregnant
结局指标
主要结局
Waist circumference (cm)
时间窗: Change from baseline waist circumference at 1-year follow-up
Appetite ratings assessed via Visual Analog Scales
时间窗: Baseline
Appetite ratings include self-reported perceived hunger, desire to eat, prospective consumption, and fullness.
Percent caloric compensation index (%COMPX)
时间窗: Baseline
Total energy intake per day (number of calories consumed over 24-hours)
时间窗: Baseline
Number of calories consumed over 24-hours assessed via measured food intake in the laboratory and via parent-reported food intake at home.
BMI z-score
时间窗: Change from baseline BMI z-score at 1-year follow-up
Percentage body fat
时间窗: Change from baseline percentage body fat at 1-year follow-up
次要结局
- Eating in the absence of hunger (kcal)(Baseline (number of calories consumed from snacks))
- Home food environment(Baseline home food environment assessed using the Home Food Inventory)