Effect of Slow Breathing and Yogic-Derived Breathing on Respiration and Cardiovascular Variability in Spinal Cord Injury Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- beat-by-beat arterial pressure
研究概览
简要总结
This research will aid in understanding of slow-breathing and its effect on heart rate and blood pressure in people with a spinal cord injury (SCI). This research will investigate if traditional 'yogic' breathing exercises can be performed by subjects with SCI and its influence on the cardiovascular system.
详细描述
The relationship between respiratory patterns and cardiovascular variability in healthy persons has been previously studied. However, the impact of SCI on the interrelationships between the respiratory and cardiovascular systems remains relatively unstudied. The loss of autonomic control in SCI may mean that slow breathing has profound effects on cardiovascular variability. Hence, those with SCI may represent a population that could benefit from the potential physiologic effects of numerous yogic-based breathing patterns that can be applied anywhere any time. Hence, it is important to determine if slower breathing patterns can shift the cardiovascular control pattern to-wards important healthful effects. This physiological study will compare the effects of uncontrolled breathing and traditional yogic slow-breathing practices on cardiovascular variability in SCI patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 18-60 years old
- •Wheelchair user
- •Medically stable & able to follow directions
- •Body mass index (18.5 - 35 kg/m2)
排除标准
- •BP >140/90 mmHg
- •Current use of cardioactive medications (except medication to support blood pressure)
- •Current tobacco use
- •Significant arrhythmia
- •Coronary artery disease
- •Renal Disease
- •Epilepsy or other neurological diseases
研究组 & 干预措施
Spinal Cord Injured Participants
17 medically stable male and female subjects between 18 and 60 years old, BMI between 18.5-35 kg/m2, with a SCI and who use a wheelchair were recruited. Participants that did not speak English or with a history of renal, neurological, or coronary artery disease, cancer, diabetes, significant arrhythmia smoking, or using cardioactive medications were excluded.
干预措施: Slow Breathing (Behavioral)
结局指标
主要结局
beat-by-beat arterial pressure
时间窗: 1,5 hour during Slow-breathing
blood pressure fluctuations via Finometer and Dinamap blood pressure cuff
respiratory excursions
时间窗: 1,5 hour during Slow-breathing
Measuring belly and chest depth of inspiration and expiration
beat-by-beat limb blood flow
时间窗: 1,5 hour during Slow-breathing
brachial blood flow via doppler
Heart Rate Variability
时间窗: 1,5 hour during Slow-breathing
R-R interval on a 5 lead Electrocardiogram (EKG)
peripheral capillary oxygen saturation (SpO2)
时间窗: 1,5 hour during Slow-breathing
blood oxygen saturation via pulse oximetry
HRV
时间窗: 7 minutes of paced or unpaced breathing
Heart rate variability assessed in the frequency domain during paced or unpaced breathing via Welch's modified periodogram method. Average power calculated by integrating the power spectral density in the low and high frequency bands.
BPV
时间窗: 7 minutes of paced or unpaced breathing
Systolic blood pressure variability from a Finometer assessed in the frequency domain via Welch's modified periodogram method. Average power calculated by integrating the power spectral density in the low and high frequency bands.
SpO2
时间窗: 7 minutes of paced or unpaced breathing
Peripheral oxygen saturation during paced or unpaced breathing
Expired Carbon Dioxide (CO2)
时间窗: 7 minutes of paced or unpaced breathing
Expired CO2 from a nasal cannula
次要结局
未报告次要终点
研究者
J. Andrew Taylor
Associate Professor of Physical Medicine and Rehabilitation, Principal Investigator
Spaulding Rehabilitation Hospital