Aspects of Self-harm - Cognition, Imaging and Treatability
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Region Skane
- 入组人数
- 316
- 试验地点
- 2
- 主要终点
- Volumetry
研究概览
简要总结
Deliberate self-harm (DSH) is a common symptom in psychiatric disorders. This study aim at increased understanding of parameters associated with DSH with the long term goal to potentially improve and possibly personalise its treatment.
In short, the study will characterise cognitive, psychiatric and demographic factors with focus on executive function and will compare results from individuals with DSH, individuals who have ceased DSH as well as psychiatric patients without DSH and individuals who never engaged in DSH. Adequate statistical tests will be used to compare groups.
Participants will be interviewed by a trained physician for basic medical history, history of self-harm and treatment for that, demographic data and diagnostic evaluation. Thereafter the participants will undergo standardised neuropsychological testing focusing on emotional response inhibition, decision making and risk taking, attention set shifting, working memory, inhibition and planning. Some participants will redo parts of this testing during fMRI, as well as undergo DTI and volumetry.
详细描述
Deliberate self-harm (DSH) is a common symptom in psychiatric disorders. Today, there is not sufficient knowledge as to why an individual continues to suffer from DSH, DSH is reduced or even ceased - regardless given treatment or not. The overall aim of this project is to characterise cognitive, psychiatric and demographic factors as well as perform brain imaging in individuals currently suffering from DSH, individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals. The intention is to gain more knowledge on factors associated with DSH and thereby potentially improve and possibly personalize treatment.
The following hypotheses will be tested:
Individuals currently suffering from DSH have lower scores on executive function than individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals.
Individuals currently suffering from DSH have lower level daily life functioning and more severe psychiatric symptoms than individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals.
Individuals currently suffering from DSH have higher scores of negative affectivity, lower scores of antagonism and lower scores of disinhibition measured with Personality Inventory for DSM-5 than individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for persistent DSH group:
- •Adults 18-65 years.
- •Ability to leave informed consent.
- •Understands and uses the Swedish language without significant difficulties.
- •Psychiatric disorder and ongoing treatment at an adult psychiatric clinic.
- •DSH at least five times during the last three months, and DSH at least ten times during at least one year.
排除标准
- •for persistent DSH group:
- •No history of DSH, and/or DSH fewer than five times during the last three months and fewer than ten times during at least one year
- •Diagnosis of Intellectual disability
- •Diagnosis of chronic psychotic disorder
- •Hearing disability, visual impairment or motor disorder that rules out the ability to complete neurocognitive tasks
- •Inclusion criteria for those who have ceased DSH group:
- •Adults 18-65 years.
- •Ability to leave informed consent.
- •Understands and uses the Swedish language without significant difficulties.
- •Psychiatric disorder and ongoing treatment at an adult psychiatric clinic.
- •No DSH during the last three months, but DSH at least ten times during at least one year.
- •Exclusion criteria for those who have ceased DSH group:
- •Any DSH during the last three months, and/or fewer than ten times during the at least one year
- •Diagnosis of Intellectual disability
- •Diagnosis of chronic psychotic disorder
- •Hearing disability, visual impairment or motor disorder that rules out the ability to complete neurocognitive tasks
- •Inclusion criteria for psychiatric disorder with no history of DSH group:
- •Adults 18-65 years.
- •Ability to leave informed consent.
- •Understands and uses the Swedish language without significant difficulties.
- •Psychiatric disorder and ongoing treatment at an adult psychiatric clinic.
- •Exclusion criteria for psychiatric disorder with no history of DSH group:
- •Any DSH during the last three months, and more than two times during lifetime
- •Diagnosis of Intellectual disability
- •Diagnosis of chronic psychotic disorder
- •Hearing disability, visual impairment or motor disorder that rules out the ability to complete neurocognitive tasks
- •Inclusion criteria for healthy control group:
- •Adults 18-65 years.
- •Ability to leave informed consent.
- •Understands and uses the Swedish language without significant difficulties.
- •Exclusion criteria for healthy control group:
- •Diagnosed with any psychiatric disorder
- •Any DSH during the last three months, and more than two times during lifetime
- •Hearing disability, visual impairment or motor disorder that rules out the ability to complete neurocognitive tasks
结局指标
主要结局
Volumetry
时间窗: Up to 1 hour
Volumes of local cerebral white matter
Executive functioning
时间窗: Up to 1 hour
Scores on cognitive tests measuring executive functioning
Level of function in daily life
时间窗: 30 days
Scores on WHODAS 2.0
Personality traits
时间窗: More than 1 year (stable)
Scores on Personality Inventory for DSM-5
Blood flow
时间窗: Up to 1 hour
Blood flow in prefrontal cortex during neurocognitive tests
次要结局
未报告次要终点
研究者
Sofie Westling
MD, associate professor
Region Skane