The Effects of Light on Glucose Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Postprandial glucose (mg/dL)
研究概览
简要总结
This study evaluates the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose and/or impaired glucose tolerance.
详细描述
Light has a major influence on the biological clock and several studies suggest that bright light during the day and dim light in the evening are beneficial for the circadian timing system. Nowadays, large parts of the population spend 90% of their time indoors and are thereby exposed to artificial lighting instead of daylight. The artificial light levels are relatively low during the day and continue relatively late in the evening. The lack of a clear natural light-dark cycle could results in delayed timing of the biological clock relative to the behaviour. Optimizing the lighting conditions under controlled laboratory settings might lead to better alignment of the biological clock, which in turn could improve metabolic parameters such as glucose control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Caucasian
- •BMI 25-35 kg/m2
- •Stable weight (+/- 3 kg in the last 3 months)
- •One of the four criteria for prediabetes:
- •Impaired fasting glucose (6.1 mM to 6.9 mM)
- •Blood glucose values 7.8 - 11.1 mM 2h after glucose drink consumption during the oral glucose tolerance test (OGTT) in screening
- •Insulin Resistance: glucose clearance rate ≤ 360 ml/kg/min, as determined using the oral glucose insulin sensitivity (OGIS120) index
- •HbA1c of 5.7 - 6.4%.
排除标准
- •Fasting plasma glucose ≥7.0 mM
- •Blood donation one month prior to study and three months after finishing study.
- •Participants with extreme chronotypes (going to bed extremely late/early).
结局指标
主要结局
Postprandial glucose (mg/dL)
时间窗: Study Day 1-3
Assessed with a continuous glucose monitor (CGM)
次要结局
- Glucose levels (mmol/L) in the postprandial state(Study Day 2-3)
- Insulin levels (µU/mL) in the postprandial state(Study Day 2-3)
- Energy expenditure(Study Day 1-3)
- Continuous interstitial glucose (mg/dL)(Study Day 1-3)
- Free fatty acid levels (µmol/L) in the postprandial state(Study Day 2-3)
- Triglycerides levels (mmol/L) in the postprandial state(Study Day 2-3)
- Core body temperature (CBT) and skin temperature(Study Day 1-3)