Are Sporadic Colorectal Cancers in Young Distinct From Elderly?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,599
- 试验地点
- 1
- 主要终点
- Overall survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC)
研究概览
简要总结
In this study, the investigators compared and evaluated the clinicopathological and oncological characteristics of sporadic colorectal cancer (CRC) in young adults without genetic mutations associated with hereditary CRC syndrome and sporadic CRC in elderly individuals.
详细描述
The ambiguity in the findings among several previous studies might be because of the difference in the age of the study population, yCRC and eCRC. The family history of CRC and cancer due to Crohn's disease or ulcerative colitis were also not excluded in such previous studies. Most importantly, those studies did not rule out the risk of hereditary cancer through the genetic testing in yCRC. Since hereditary CRC accounts for approximately 34% of those under the age of 35 years, it is necessary to exclude it to accurately compare the clinicopathological characteristics of sporadic cancer developed in yCRC and eCRC.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed cases of adenocarcinoma in the colon and rectum
- •The age at the time of diagnosis should be ≤ 40 years (for yCRC) or ≥ 70 years (for eCRC)
- •Genetic testing confirmation of non-hereditary cancer.
排除标准
- •Inflammatory bowel disease
- •A family history of CRC
- •A history of other cancers
- •Underwent any emergency operation or palliative surgery
- •The Amsterdam criteria with mutations in genes associated with APC, MLH1, MSH2, MSH6
结局指标
主要结局
Overall survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC)
时间窗: The OS was defined as the time period from the date of surgery to the date of death or last follow-up up to 3 years
The 3-year overall survival (OS) in yCRC and eCRC
次要结局
- Cancer-specific survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC)(CSS was defined as the time period from the date of surgery to the date of death from CRC up to 3years)