Healthcare Disparities in Alopecia Areata: UK Population-based Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4,052,231
- 试验地点
- 1
- 主要终点
- Likelihood of Depressive Episodes
研究概览
简要总结
Alopecia areata (AA) is a common immune-mediated non-scarring alopecia often associated with substantial morbidity. There are however, limited population-based data on potential disparities in the burden of AA, including across people of different ethnicities and deprivation.
We aimed to provide the first large-scale, population-based estimate of lifetime risk of AA overall and by important sociodemographic subgroups. As AA is associated with an increased burden of mental health conditions and work-related outcomes (unemployment, time off work), a detailed understanding of the burden of disease in different sociodemographic groups is vital to plan resource provision.
详细描述
The overall purpose of the study is to provide an estimate of the cumulative lifetime incidence of AA in the population overall and by important sociodemographic groups. Moreover, to do a subgroup analysis in the AA population to identify health-related disparities across people in different socioeconomic strata, geographical distribution, sex and ethnic groups. The disparities that will be considered are AA associated: Mental health conditions; healthcare utilisation; and work impact (time off work and unemployment).
The cumulative lifetime risk of AA was estimated at age 80 years (approximate life expectancy in the UK) using survival models, with age as the timescale and accounting for the competing risk of death.
The assessment of any associations with baseline characteristics and the outcomes of interest will be assessed using Cox proportional hazards models (time to event outcomes) and Poisson regression (repeated event outcomes) models.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 12 Years 至 95 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged greater than 12 over the study period.
- •Registered with the contributing primary care practice for any duration during the study period
排除标准
- •People diagnosed with AA before the study period.
结局指标
主要结局
Likelihood of Depressive Episodes
时间窗: Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant
Estimated using logistic regression and reported using adjusted odds ratios
Likelihood of Recurrent Major Depressive Disorder
时间窗: Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant
Estimated using logistic regression and reported using adjusted odds ratios
Likelihood of Anxiety Disorder
时间窗: Data was collected retrospectively, assessed prior to and up to two years following initial Alopecia Areata diagnosis for each participant
Estimated using logistic regression and reported using adjusted odds ratios
次要结局
- Relative Incidence of Primary Care Attendances(Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant)
- Relative Incidence of Dermatology Referrals(Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant)
- Relative Incidence Psychological Therapy(Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant)
- Relative Incidence of Unemployment(Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant)
- Relative Incidence of Time Off Work(Data was collected retrospectively, assessed up to two years following initial Alopecia Areata diagnosis for each participant)