Comparison of Cortical Excitability and Typing Performance Across Action Observation, Motor Execution, and Control Conditions
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in Resting Motor Threshold (RMT)
研究概览
简要总结
Goal:
This study will aim to investigate the effects of different motor stimulation strategies-motor execution (ME) and action observation (AO)-on cortical excitability and typing performance in healthy individuals.
Recruitment:
A total of 60 healthy university students will be recruited and randomly assigned into three groups:
Motor Execution group (n=20) Action Observation group (n=20) Control group (n=20)
Evaluation Tools:
Transcranial Magnetic Stimulation (TMS) using DEYMED DuoMAG XT will be used to measure Resting Motor Threshold (RMT), Motor Evoked Potential (MEP) Amplitude, and MEP Latency of the First Dorsal Interosseous (FDI) muscle.
Online Typing Test will be used to assess typing speed (words per minute) and accuracy (percentage of correct characters).
Intervention:
The ME group will perform a 3-minute typing task. The AO group will observe a 3-minute first-person video of typing. The Control group will not receive any intervention between assessments.
All participants will undergo TMS and typing assessments twice, once before and once after the intervention.
详细描述
This study will be designed as a randomized controlled trial to compare the effects of motor execution (ME) and action observation (AO) on cortical excitability and fine motor performance, using typing as the target motor task.
A total of 60 healthy university students will be recruited from the University of Sharjah through convenience sampling. Participants will be screened based on inclusion and exclusion criteria and will provide informed consent prior to enrollment. Eligible participants will then be randomly assigned into three groups (ME, AO, and Control), with stratification based on baseline typing proficiency to ensure balanced motor skill levels across groups.
All participants will undergo a pre-assessment session that will include a 3-minute typing task focused on the index finger and TMS testing targeting the First Dorsal Interosseous (FDI) muscle. TMS measures will include Resting Motor Threshold (RMT), MEP Amplitude, and MEP Latency.
During the intervention phase:
The ME group will perform the typing task for 3 minutes. The AO group will watch a 3-minute point-of-view video of the same typing task. The Control group will receive no intervention and will simply wait between the assessments.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
This will be a double-blinded randomized controlled trial in which participants will be unaware of their group allocation or the purpose of the intervention they receive. Outcome assessors and data analysts will also be blinded to the group assignments. To ensure assessor blinding, TMS and typing data will be coded and analyzed by an independent researcher who is not involved in intervention delivery or participant interaction. The interventions (ME, AO, Control) will be conducted in a standardized format, minimizing interaction and disclosure that could bias results.
入排标准
- 年龄范围
- 18 Years 至 26 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 18 and 26 years
- •Healthy university students with no known neurological, psychiatric, or musculoskeletal conditions
- •Intact motor functioning of the upper limbs
- •Basic typing proficiency using a 10-finger typing method
- •Ability to understand study procedures and provide informed consent
排除标准
- •Typing speed less than 16 words per minute
- •Use of hunt-and-peck or single-finger typing style
- •History of seizures or epilepsy
- •Current use of neuroactive medications
- •Presence of metallic implants in the head or upper body
- •Any contraindications to Transcranial Magnetic Stimulation (TMS)
- •Left-handed individuals using non-standard typing techniques (unless provided with adapted materials)
结局指标
主要结局
Change in Resting Motor Threshold (RMT)
时间窗: Pre-intervention (Day 1) and Post-intervention (within 15 minutes after intervention on Day 2, between 48 hours to a 3-week window)
Resting Motor Threshold (RMT) will be measured using Transcranial Magnetic Stimulation (TMS) targeting the First Dorsal Interosseous (FDI) muscle. RMT is defined as the minimum stimulation intensity required to evoke a measurable motor evoked potential (MEP) of ≥50 µV in at least 5 out of 10 trials.
Change in MEP Latency and Amplitude
时间窗: Pre-intervention (Day 1) and Post-intervention (within 15 minutes after intervention on Day 2, between 48 hours to a 3-week window)
Motor Evoked Potential (MEP) latency (in milliseconds) and amplitude (in µV) will be assessed using TMS. These measures reflect neural conduction time and the magnitude of cortical response, respectively.
Change in Typing Speed (Words Per Minute)
时间窗: Pre-intervention (Day 1) and Post-intervention (within 15 minutes after intervention on Day 2, between 48 hours to a 3-week window)
Typing speed will be measured using a standardized online typing platform, expressed in words per minute (WPM). Participants will complete a 3-minute typing task using custom text emphasizing index finger usage.
Change in Typing Accuracy
时间窗: Pre-intervention (Day 1) and Post-intervention (within 15 minutes after intervention on Day 2, between 48 hours to a 3-week window)
Typing accuracy will be recorded as the percentage of correctly typed characters during a 3-minute standardized typing task using an online platform.
次要结局
未报告次要终点
研究者
Meeyoung Kim
Assistant professor
University of Sharjah