IRCT20120703010178N18招募中3 期
The efficacy and safety of intravenous colistin plus nebulized colistin against intravenous ampicillin-sulbactam plus nebulized colistin in treating ventilator associated pneumonia caused by Acinetobacter baumannii
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 28
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 no limit（—）
- 性别
- All
入选标准
- •Participant with endotracheal intubation days > 48 hours
- •Pneumonia diagnosis as clinical features (which include the new onset of fever (T > 38), purulent sputum, leukocytosis or leukopenia (WBC > 11000 cells/mm3 or < 4000 cells/mm3), biologic (microorganism concentration in sputum >?10?^5 CFU/ml) and radiographic evidences (new lung infiltrates)
- •Sputum culture of Acinetobacter baumannii
排除标准
- •History of hypersensitivity reactions to beta-lactam antibiotics or colistin
- •Have received effective antibiotics for this episode of ventilator associated pneumonia for more than 72 hours before study medication administration
- •Patients on dialysis
- •Immunodeficiency (HIV with CD4 < 200 cells/mm3, ANC < 500/mm3? leukemia, lymphoma, chemotherapy within the last 3 weeks)
- •Sever Acute respiratory distress syndrome (PaO2/Fio2 < 100)
- •Endobronchial obstruction such as stenosis or mass in the endobronchial
- •Sever bronchospasm
- •Lung abscess
- •Chest trauma
- •Co-infection in another organs
- •Comorbidities: cystic fibrosis? myasthenia or atelectasis
- •Pregnancy and lactation
研究者
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