A Prospective Cohort Study of Early Detection and Screening Strategy for Gatric Cancer in Sichuan Province China (SIGES-01)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30,000
- 试验地点
- 1
- 主要终点
- The number of new cases of gastric carcinoma
研究概览
简要总结
To establish prospective cohort of healthy population and corresponding serum sample bank in Sichuan province to provide platform for exploring early diagnosis and screening strategy of gastric cancer by a prospective cohort study.
详细描述
H. pylori was one of the most important carcinogenic factor for gastric cancer and play a crucial role in inducing gastritis, atrophy and canceration. Chronic atrophic gastritis (CAG) was a common precancerous disease, people with CAG become high-risk population and need regular follow-up. However, study about occurrence risk prediction for gastric cancer when H. pylori infection concurrence with CAG was still spare. In especial, there was still no population screening program based on serology. The relative clinical epidemiology for providing evidence for China gastric cancer screening program was very rare.
This study aim to evaluate gastric cancer occurrence risk and diagnostic value of people combined with H. pylori infection and CAG by Serological methods in Sichuan province China. We also project to design optimized screening program suitable for people in sichuan province China.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inhabitant in Sichuan province in China (length of residence > 10 years);
- •Complete physical examination in our hospital, the outcomes was asymptomatic and cancer free healthy individuals;
- •Age between 20 and 70;
- •With normal cognitive and communication ability;
- •Without gastroscopy during recruitment, physical examination item including gastroscopy enrolled in prospective cohort study;
- •Wiling to accept 1-2 times routine physical examination in our hospital;
- •Agree to accept the follow-up of our project group;
排除标准
- •With history of malignant tumor;
- •Refuse to donate blood specimen;
- •With serious comorbidity and/or finite life (less than 5 years);
- •Request to retreat from this study;
结局指标
主要结局
The number of new cases of gastric carcinoma
时间窗: 5 years
The new cases of gastric and other epidermal malignant tumor
次要结局
- Time of finding nee cases(5 years)
研究者
Jian-Kun Hu
Vice director of Gastrointestinal Surgery department, West China Hospital; Director of Institute of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital
West China Hospital