A PROSPECTIVE COMPARATIVE STUDY OF ARTERIAL BLOOD GAS PARAMETERS IN SMOKER VS NONSMOKER PATIENTS UNDERGOING LAPAROSCOPIC ABDOMINAL SURGERY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- compare the abga changes between chronic smokers vs non-smokers in laparoscopic abdominal surgery
研究概览
简要总结
Laparoscopic surgery is minimally invasive, creation of pneumo-peritoneum and postural changes associated with it causes a number of physiological alterations which may have an effect on the anaesthesia management and warrant specific caution. Absorption of carbon dioxide (CO2) used in insufflation can cause hypercapnia and respiratory acidosis. This further activates the sympathetic nervous and also sensitises the myocardium to catecholamines.This along with a decrease in preload and venous return due to increased intraabdominal pressure may cause a gross decrease in cardiac output. Chronic smoking (more than 20 pack-year at least for 10 years) causes a number of pathological changes in the respiratory system .As the lung function is already in a compromised state in chronic smokers, creation of pneumoperitoneum for laparoscopic surgeries in such patients further aggravates and causes an alteration in the acid-base status of the body. The aim of this study is to compare the changes in metabolic and gas exchange status between chronic smokers versus non-smokers in patients posted for laparoscopic abdominal surgery by analyzing blood gas parameters.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 20-60yrs.
- •ASA 1 and
- •Elective laparoscopic surgeries.
排除标准
- •Patient refusal.
- •ASA 3 and
- •Patients with other lung and cardiac pathologies.
- •Patients with hypertension, uncontrolled diabetes mellitus, systemic infection,, history of malignancy, history of alcohol or drug abuse.
- •Emergency operation.
结局指标
主要结局
compare the abga changes between chronic smokers vs non-smokers in laparoscopic abdominal surgery
时间窗: 10 minute prior to premedication,10 minute after gas insufflation intraoperative and 10 minute after extubation postoperative period
次要结局
- To take proper precautions to avoid complications due to gas insufflation in laparoscopic surgery.(Intraoperative period and postoperative period up to 12hours.)