The development of a thirst provocation test using the AVP receptor antagonist Tolvaptan for quantification of thirst sensation in various patient groups (obese patients with and without a history of bariatric surgery, patients with congestive heart failure and patients with cranial diabetes insipidus as compared to healthy controls) and genotyping of the AVP receptor 2. - Tolvaptan Thirst Research Project (TTReP)

Reinier de Graaf Groep0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•1. Informed consent signed by all healthy probands and patients
•2. Male and female probands and patients, age 18 - 65 years
•3. For obese patients with a history of Bariatric Surgery: Pre-BS BMI >27 Kg/m2
•4. For obese patients without a history of BS: BMI >27 Kg/m2
•5. For obese patients with a history of BS: operation at least 2 years ago, stable weight for at least a year

•1. Unwillingness to cooperate with the study procedures
•2. History of an active malignancy
•3. No written informed consent
•4. Pregnancy
•5. Breastfeeding
•6. Urinary tract obstruction like benign prostate hyperplasia, or patients otherwise unable to void
•7. (A history of) electrolyte disturbances or renal failure
•8. Diabetes mellitus (as this can cause pseudohyponatraemia)
•9. Lactose- or galactose intolerance
•10. Clinical signs of dehydration
•11. Failure to meet the inclusion criteria

发起方

Reinier de Graaf Groep