The Effects of a Lutein + Zeaxanthin Intervention on Cognitive Function and Neural Efficiency
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- macular pigment optical density
研究概览
简要总结
Past research suggests that retinal lutein levels are related to cognitive function as measured via behavioral tests. The goal of the present study is to investigate the relationship between lutein and cognitive function in a wider variety of the population (young, healthy adults and older adults), using a wider variety of methods (behavioral testing and neuroimaging).
详细描述
Past research suggests that retinal lutein levels are related to cognitive function as measured via behavioral tests. The goal of the present study is to investigate the relationship between lutein and cognitive function in a wider variety of the population (young, healthy adults and older adults), using a wider variety of methods (behavioral testing and neuroimaging).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •visual acuity correctable to 20:40 or better, Snellen notation
- •able to swallow a dietary supplement
- •free of dementia, characterized by a score of less than 1.5 on the Clinical Dementia Rating Scale
排除标准
- •GI conditions that interfere with lipid absorption
- •presence of or past diagnosis of age-related macular degeneration
- •visual acuity poorer than 20:40, Snellen notation
- •has taken lutein, omega-3 fatty acid or fish oil supplements within the last 6 months
- •presence of dementia, characterized by a score of 1.5 or greater on the Clinical Dementia Rating Scale
研究组 & 干预措施
Active supplement
10 mg lutein + 2 mg zeaxanthin
干预措施: active supplement (Dietary Supplement)
inert placebo
placebo for comparison
干预措施: placebo (Other)
结局指标
主要结局
macular pigment optical density
时间窗: 12 months
optical density of macular pigment layer in central retina, defined in log units of optical density
次要结局
- reaction time(12-months)
- serum carotenoid levels(12 months)
- executive function(12-months)
- short-term memory(12-months)
- visual attention(12-months)
研究者
Billy R. Hammond
Professor and Principal Investigator
University of Georgia