Role of the renin-angiotensin system in the cardiovascular, metabolic, neurologic and respiratory response to hypobaric hypoxia during sustained exposure to high altitude. - HIGHCARE

ISTITUTO AUXOLOGICO ITALIANO0 个研究点开始时间: 2008年2月8日最近更新: 2014年1月27日

适应症

试验速览

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•Group A: ? male and female volunteers aged 20 to 65 years with high altitude climbing expertise (including professional climbers) ? informed consent to study procedures Group E ? male and female volunteers residing at low altitude aged 20 to 65 years ? informed consent to study procedures
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•? chronic therapy with cardiovascular drugs, beta-mimetics and other drugs that may interfere with the physiological mechanisms under study or may be unsafe in high altitude conditions ? pregnancy ? repeated exposures to altitudes >3000 m a.s.l. in the 8 months preceding the expedition ? history of severe AMS forms including HAPE and HACE ? relevant chronic diseases (any chronic cardiovascular or renal disease, diseases that reduce functional capacity, infectious diseases) ? relevant diseases in the past (pneumothorax, major thoracic traumas, major surgical procedures etc.)

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