Personalized Medicine in Patients With Infective Endocarditis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- To characterize a cohort of patients diagnosed with infective endocarditis
研究概览
简要总结
The hypothesis underlying this work is the identification of different sub phenotypes of patients with infective endocarditis through the study of the host's response to infection.
Furthemore, metagenomic sequencing may be a helpful supplement to IE diagnostic, especially when conventional tests fail to yield a diagnosis.
详细描述
Infective endocarditis is a life-threatening infection of heart valves and adjacent structures characterized by vegetations on valves and other endocardial surfaces, with tissue destruction and risk of embolization.
The clinical variability, including the heterogeneous response to infection and the different antibiotic treatments make the identification of the underlying pathogens of infective endocarditis (IE) is critical for precision therapy. Virulence factors mediate tissue adherence, host infiltration, immune resistance/evasion, and dynamic stress responses and confer enhanced pathogen survival, proliferation, and host invasion in animal models of infective endocarditis.
To identify the microorganism and simultaneously considered the response of the host to the infection could improve the management of the infective endocarditis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of active infective endocarditis according to the modified Duke criteria.
排除标准
- •Pregnancy
结局指标
主要结局
To characterize a cohort of patients diagnosed with infective endocarditis
时间窗: 2 year
Clinical, microbiological and echocardiographic description of patients with infective endocarditis.
次要结局
- Host response classification for infective endocarditis (IE)(2 year)
- Identification of the underlying pathogens of infective endocarditis (IE)(2 year)
- Host response predictors of sepsis outcomes(2 year)