Enhancing Prospective Thinking in Early Recovery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Increase Prospective Thinking
研究概览
简要总结
The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. The main question[s] this trial aims to answer are:
- Will high-intensity EFT cues will produce greater delayed reward preference than low-intensity cues?
- Will high-intensity EFT cues effect greater treatment-seeking interest?
- Will high-intensity EFT cues elicit greater response in regions for prospective thinking during delay discounting (vs. low-intensity)
- Will nucleus accumbens-precuneus resting connectivity correlate with behavioral SS?
- Will the novel behavioral SS decision-making task activate the nucleus accumbens?
Researchers will compare the experimental (high-intensity group) and control (low-intensity) groups to see if there are differences in the results for the questions outlined above.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
盲法说明
Eligible participants will be randomly assigned to either the high-intensity (experimental) or low-intensity (control) groups.
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals who meet current heavy drinking (≥2 heavy drinking days/month OR ≥7 drinks/week for biological females, and ≥14 drinks/week if biological male [NIAAA definition] and/or AUDIT scores ≥8)
- •English comprehension
排除标准
- •Unstable medical disorders
- •Outside the age range of 18-60
- •Smell/taste disorders
- •Unstable psychiatric conditions
研究组 & 干预措施
High-Intensity
Participants will receive high-intensity episodic future-thinking cue images, and high-intensity episodic recent-thinking cue images during an MRI decision-making task.
干预措施: High-Intensity Cue (Behavioral)
Low-Intensity (Control)
Participants will receive low-intensity episodic future-thinking cue images, and low-intensity episodic recent-thinking cue images during an MRI decision-making task.
干预措施: Low-Intensity Cue (Behavioral)
结局指标
主要结局
Increase Prospective Thinking
时间窗: Study Day Visit (Day 1)
High-intensity episodic future-thinking image cues will change prospective thinking.
Delayed Rewards
时间窗: Study Day Visit (Day 1)
High-intensity episodic future-thinking image cues will change preference for delayed rewards, which will be measured using a behavioral delayed discounting task.
次要结局
未报告次要终点
研究者
Brandon G. Oberlin, PhD
Assistant Professor
Indiana University