Test-retest Fidelity of a Tool for Calculation of Muscle Synergies
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 12
- 试验地点
- 6
- 主要终点
- Changes in Muscle Synergy Composition derived by non-negative matrix factorization.
研究概览
简要总结
This study investigates how the anticipation of pain affects muscle synergies. One group will be recruited who will first experience actual pain from capsaicin cream and are then presented with a harmless cream deceptively labeled as capsaicin. The changes in muscle synergies will be measured during walking tasks.
详细描述
Participants will be recruited through university announcements. Eligibility will be determined by a screening process that assesses prior experience with capsaicin cream. Healthy adults aged 18-35 who meet the inclusion criteria will be enrolled and assigned to experimental Group ("Prior Experience"): Individuals who report a prior painful experience with capsaicin cream.
Participants will complete a first session consisting on a walking assessment on a treadmill. The speed will be incrementally increased from 0.8 m/s to 1.1 m/s. Throughout this task, muscle activity will be recorded via electromyography (EMG), and ground reaction forces will be captured by force platforms embedded in the treadmill.
Following the initial walk, participants will complete a set of standardized questionnaires to establish baseline scores for pain perception (Visual Analog Scale, VAS), fear of movement (Tampa Scale of Kinesiophobia, TSK), and pain catastrophizing (Pain Catastrophizing Scale, PCS).
Then, a capsaicin cream will be applied to the knee, specifically in the area between the lateral epicondyles of the femur, in a 4 cm wide band. Participants will immediately fill out the VAS to report any pain sensations. The walking assessment is repeated, measuring the same physiological signals (EMG and ground reaction forces).
The participants will come to the laboratory a second time to measure the same outcomes but, instead of applying capsaicin again, they will receive an inert cream presented as capsaicin (neutral massage cream MEDICAFARM). The procedure will be repeated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None (Participant)
盲法说明
Participants are not aware that a cream applied to them (neutral cream) does not produce any pain.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 18-35 years old
- •Healthy participant with no self-reported diagnosed neurological, musculoskeletal, or cardiovascular disorders
- •Body Mass Index (BMI) < 30
- •Ability to walk unaided for at least 10 minutes without major physical limitations
排除标准
- •Presence of pain at the time of testing
- •Self-reported diagnosed condition affecting mobility
- •Known allergy to any component of the study cream
- •Allergy to EMG electrode adhesives
- •Inability to stand unassisted for more than 1 minute
- •Inability to walk/run at the required speed and distance
- •Weight exceeding 150 kg (due to treadmill limitations)
- •Recent intake (prior intervention) of:
- •Analgesics (within 6 hours)
- •Cigarettes (within 6 hours)
- •Caffeine (within 2 hours)
- •Skin lesions at the cream application site
- •Pregnancy
- •Failure to understand instructions
- •Daytime pain reported by participant on day of experimentation
研究组 & 干预措施
Prior Experience Group
Participants in this arm have experienced capsaicin cream before and will be given a neutral cream. They will be told that the cream contains capsaicin and will cause pain.
干预措施: Pain expectation conditioning (Other)
Prior Experience Group
Participants in this arm have experienced capsaicin cream before and will be given a neutral cream. They will be told that the cream contains capsaicin and will cause pain.
干预措施: Gait assesment (Other)
Control Group
Pariticpants in this arm have never experienced capsaicin cream before and will be given a neutral cream. They will be told that the cream contains capsaicin and will cause pain.
干预措施: Pain expectation conditioning (Other)
Control Group
Pariticpants in this arm have never experienced capsaicin cream before and will be given a neutral cream. They will be told that the cream contains capsaicin and will cause pain.
干预措施: Gait assesment (Other)
结局指标
主要结局
Changes in Muscle Synergy Composition derived by non-negative matrix factorization.
时间窗: Before intervention, after intervention (10 minutes after cream application)
Changes in the composition of muscle synergies (i.e., the individuals muscles that comform one muscle synergy)
Distribution of muscle synergies derived by non-negative matrix factorization
时间窗: Before intervention, after intervention (10 minutes after cream application)
Changes in the activation of the muscle synergies during the gait cycle.
Changes in Muscle Synergy Composition derived by non-negative matrix factorization.
时间窗: Before intervention, after intervention (10 minutes after cream application)
Changes in the composition of muscle synergies (i.e., the individuals muscles that comform one muscle synergy)
次要结局
- Self-Reported Pain (VAS)(Before cream application of the cream (pre-intervention) and 10 minutes after cream application (post-intervention).)
- Force reactions(Before intervention, after intervention (10 minutes after cream application))
- Pain Catastrophizing (PCS)(Before intervention.)
- Tampa Scale for Kinesiophobia (TSK)(Before intervention.)
- Pain Catastrophizing (PCS)(Before intervention.)
- Tampa Scale for Kinesiophobia (TSK)(Before intervention.)
- Self-Reported Pain (VAS)(Before cream application of the cream (pre-intervention) and 10 minutes after cream application (post-intervention).)
- Force reactions(Before intervention, after intervention (10 minutes after cream application))
研究者
Jennifer Burgos Tirado
Researcher - Ph.D student
Universite de Picardie Jules Verne