Westlake Nutrition and Brain Health Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,425
- 试验地点
- 1
- 主要终点
- Continuous blood glucose profile over 2 weeks
研究概览
简要总结
The Westlake Nutrition and Brain Study (WEBRAIN), a sub-study of the Guangzhou Nutrition and Health Study, is a prospective cohort study of residents in Guangzhou city. WEBRAIN aims to explore the links between diet, gut microbiome, and brain health in elderly individuals through comprehensive phenotyping, including continuous blood glucose monitoring for standardized test meals, objective physical activity measurement, and brain magnetic resonance imaging.
详细描述
The gut-brain axis is implicated in neurodegenerative diseases through various mechanisms, with diet and nutrition linked to both gut and brain health. However, most evidence comes from animal models or small-scale human studies.
The Westlake Nutrition and Brain Study (WEBRAIN) aims to investigate the relationships among diet, gut microbiome, and brain structure and function in a large human cohort through comprehensive phenotyping: 1) objective physical activity measurement using accelerometers over two weeks; 2) continuous blood glucose monitoring for two weeks, including two standardized test meals, alongside traditional dietary assessment via Food Frequency Questionnaires (FFQ) and 24-hour recalls; 3) assessment of cognitive function and brain imaging using the Addenbrooke's Cognitive Examination-Revised (ACE-R) and brain MRI; and 4) gut microbiome profiling analysis using sequencing techniques.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants from the Guangzhou Nutrition and Health Study, lived in Guangzhou, China, and aged 45 years or older;
排除标准
- •Metal implants and other contraindications for magnetic resonance imaging scanning
结局指标
主要结局
Continuous blood glucose profile over 2 weeks
时间窗: at enrollment
Glucose levels were measured by a continuous glucose monitor over 2 weeks.
Brain images
时间窗: at enrollment
Brain structure and function were measured by brain magnetic resonance imaging (MRI).
次要结局
- Cognitive scores(at enrollment)
- Incidence of Alzheimer's disease (AD)(6 and 10 years after enrollment)
- Structure of gut microbiome profile(At enrollment)