ISRCTN76560285已完成未知
Comparison of vinorelbine versus docetaxel, and trastuzumab versus no trastuzumab as adjuvant treatments of early breast cancer
Finnish Breast Cancer Group, HYKS Institute0 个研究点目标入组 1,010 人开始时间: 2005年4月19日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 1,010
研究概览
简要总结
- 2006 results in: http://www.ncbi.nlm.nih.gov/pubmed/16495393 2. 2009 results in: http://www.ncbi.nlm.nih.gov/pubmed/19884557 3. 2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/24608200 4. 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29482642 5. 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29535130 (added 20/11/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •1. Histologically confirmed breast cancer
- •2. Age 65 or less
- •3. Progesterone receptor (PgR) and human epidermal growth factor receptor two (HER2) status available
- •5. Written informed consent
- •6. Estimated risk of breast cancer recurrence more than 25% within the first five years from the diagnosis: pN+ or pN0 with tumor size more than 20 mm and PgR negative
排除标准
- •1. Special type of histology without axillary lymph node metastases
- •2. World Health Organisation (WHO) performance status (PS) more than one
- •3. Blood leukocyte count less than 3.0 or granulocyte count less than 1.5, thrombocyte count less than 120
- •4. Severe cardiac disease or hypertension
- •5. Severe liver disease
- •6. Pregnancy
- •7. Male breast cancer
- •8. More than 12 weeks between breast surgery and study entry
- •9. Prior cancer except for basalioma/any in situ cancer
研究者
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