Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Correlation of scBAT volume and cold induced thermogenesis as determined by indirect calorimetry
研究概览
简要总结
Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance. Currently, the imaging method of choice to assess BAT morphology and function is 18F-FDG-PET/CT which is expensive and exposes patients or healthy volunteers to ionizing radiation, thus impeding larger prospective studies.
Magnetic resonance imaging (MRI) could constitute a suitable alternative and preliminary small-scale studies are promising.
The overall aim of this research proposal is to develop reliable magnetic resonance imaging techniques to facilitate the study of brown adipose tissue in human adults, specifically in the context of endocrine disease.
Specifically, investigators want to
- Develop a reliable MR imaging protocol for human BAT and compare BAT volume to cold induced nonshivering thermogenesis as a measure of BAT activity.
- Assess the intra-individual variance of BAT volume measured by MRI.
- Evaluate direct measurement of BAT temperature by functional MRI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Age 18-40 years
- •Body mass index (BMI): 17.5-27 kg/m²
排除标准
- •known concomitant disease influencing thyroid hormone metabolism
- •severe diseases: chronic heart failure, liver cirrhosis, kidney failure, active cancer
- •known hypersensitivity to cold, e.g. primary or secondary Raynaud's syndrome
- •abuse of alcohol or illicit drugs
- •Women who are pregnant or breast feeding
- •Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
- •Previous enrolment into the current study
- •implanted device not compatible with MRI, e.g. pace maker
结局指标
主要结局
Correlation of scBAT volume and cold induced thermogenesis as determined by indirect calorimetry
时间窗: both measurements within 2 weeks
measurement of scBAT volume and measurement of cold induced thermogenesis as determined by indirect calorimetry, both values measured in a timeframe of two weeks
次要结局
未报告次要终点