NCT06272123招募中不适用
Comparison of Endotypic Stability in Various Populations With Chronic Sinusitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Endotypic markers
研究概览
简要总结
A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with Chronic sinusitis (with or without polyps)
- •Undergoing endoscopic sinus surgery during the study period
- •More than 18 years
- •No chronic illness/ malignancy
排除标准
- 未提供
结局指标
主要结局
Endotypic markers
时间窗: 1 year
The primary outcome measure assessed through this study is the presence of endotypic markers including: IL-5, IFN-gamma, IL-17a, TNF-alpha, and IL-22 in tissue biopsy samples across multiple racial/ethnic groups.
次要结局
- SF-36(1 year)
- SNOT-22(1 year)
研究者
研究点 (1)
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