Individualized Precise Localization of rTMS on Precentral and Parietal Gyrus and Its Effects on Dorsal Anterior Cingulate Cortex
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- degree of enhanced neuro-activity associated with target-specific treatment
研究概览
简要总结
Attention deficit hyperactivity disorder (ADHD) patients have some problem with sustained attention. The dorsal anterior cingulate cortex (dACC) plays a key role for attention control. It has been found that the dACC has strong functional connectivity with ipsilateral motor area and parietal gyrus. Repetitive Transcranial Magnetic Stimulation (rTMS) is a sage and painless technique to activate cortical areas. The deep brain structure can be activated via stimulating superficial cortex by rTMS. For investigating the mechanism of sustained attention, this project is using functional magnetic resonance imaging (fMRI) to individualize the precise localization in motor area and parietal gyrus, and combining rTMS to activate the dACC.
详细描述
Healthy subject is recruiting in this project. High rTMS will be performed. The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 19 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •There are activation in dACC, motor area and parietal gyrus during the task fMRI
- •The head motion less than 2 mm in translation or 2 degrees in rotation in any direction during the resting-state fMRI
排除标准
- •Without any neuropsychiatric conditions
- •No head injury or history of epilepsy
- •Not on any medications
研究组 & 干预措施
Real rTMS (parietal gyrus)
Real rTMS targeting parietal gyrus for 30 min
干预措施: rTMS (Device)
Real rTMS (motor area)
Real rTMS targeting motor area for 30 min
干预措施: rTMS (Device)
Real rTMS (both brain area)
Real rTMS targeting motor area and parietal gyrus for 15 min, separately
干预措施: rTMS (Device)
Sham rTMS
Sham rTMS targeting motor area and parietal gyrus for 15 min, separately
干预措施: rTMS (Device)
结局指标
主要结局
degree of enhanced neuro-activity associated with target-specific treatment
时间窗: through study completion, an average of 1 year
amplitude of low frequency fluctuation
次要结局
未报告次要终点
研究者
Yu-Feng ZANG
Professor
Hangzhou Normal University