Acute effect of the renally excreted low-calorie sweetener, acesulfame potassium (Ace-K), on urinary glucose excretion in people with type 2 diabetes.

The University of Adelaide0 个研究点目标入组 17 人开始时间: 2023年1月27日最近更新: 2024年7月8日

适应症

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•Type 2 diabetes (American Diabetes Association criteria) treated by diet and/or one or two oral glucose-lowering agents (on stable doses over the last 3 months) except for SGLT2 inhibitors
•- Body mass index (BMI) from 20 to 40 kg/m2, and body weight over 70 kg
•- Males and females, aged from 40 to 79 years
•- Glycated haemoglobin (HbA1c) above 6.0%, but less than 7.9%
•- Haemoglobin above the lower limit of the normal range (ie. above 135g/L for men and 115g/L for women), and ferritin above the lower limit of normal (ie. above 30ng/mL for men and above 20mg/mL for women)

•- Habitual use of more than one serve of any food or beverage containing a LCS per day during the past 3 months, ascertained using a LCS frequency questionnaire.
•- Evidence of drug abuse, consumption of more than 20 g alcohol or 10 cigarettes on a daily basis
•- History of any form of heart disease or symptoms of syncope or pre-syncope (including feeling lightheaded or dizzy, feeling unsteady when standing, unexplained falls, fainting, unexplained changes in vision, such as blurring or tunnel vision)
•- Other significant illness, including epilepsy, cardiovascular or respiratory disease
•- Impaired renal or liver function (as assessed by calculated creatinine clearance less than 60 mL/min or abnormal liver function tests (more than 2 times upper limit of normal range))
•- Donation of blood within the previous 3 months
•- Participation in any other research studies within the previous 3 months
•- Inability to give informed consent
•- Vegetarians

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