Platelet Transfusion and Repeat Thromboelastography With Platelet Mapping (TEG-PM) in Patients With Severe Traumatic Brain Injuries (TBI) on Antiplatelet Therapy
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 225
- 试验地点
- 1
- 主要终点
- Repeat TEG
研究概览
简要总结
The aim of this study is to see if administering platelets (cells in our blood that stop or prevent bleeding) results in improved platelet function and slows/stops the progression of a head bleed for patients who have a traumatic head bleed and are on antiplatelet therapy (medications that stop blood cells from forming a blood clot) prior to admission.
详细描述
This study aims to determine if platelet function has improved following platelet transfusion by prospectively performing repeat thromboelastographic with platelet mapping (TEG-PM) assays on all patients consented and enrolled in the study. This study will also examine the rate of progression or stability of ICH on repeat head CT following platelet administration and will aid in the determination of a potential association between repeat CT head findings and the repeat TEG-PM results.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Repeat TEG
时间窗: 1 hour after platelets given
Rate of reversed pathway inhibition on repeat thromboelastography with platelet mapping (TEG-PM) when platelets are administered to TICH patients who are on antiplatelet therapy prior to admission.
Repeat Head CT
时间窗: From the time of interventional platelet administration until the time of patient discharge from their index admission, assessed up to 100 weeks.
Number of patients with improved platelet function on repeat TEG-PM and stability of TICH on subsequent CT scan.
次要结局
- Need for Neurosurgical Intervention(During index admission for traumatic intracranial hemorrhage (TICH), assessed through study completion, an average of 2 years.)
- Discharge Status(From the time of interventional platelet administration until the time of patient discharge from their index admission assessed through study completion, an average of 2 years.)
研究者
Lindsey Perea
Trauma and Acute Care Surgeon
Lancaster General Hospital