Growth Hormone Co-treatment With the Microflare Stimulation Protocol in IVF/ICSI, Can it be a New Hope for Poor Responders?
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 145
- 试验地点
- 1
- 主要终点
- Clinical pregnancy rates
研究概览
简要总结
The effect of use of the microflare down regulation protocol on the outcome of the IVF/ICSI cycles in poor responders
详细描述
The microflare as a method of down regulation protocol can be used to prepare the females suffering from poor ovarian reserve to undergo IVF/ICSI cycles. In this study we are trying to outline its effect on the clinical pregnancy rate as a main primary outcome, and to compare its use with the addition of growth hormone to the same protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •females fulfilling the criteria of the ESHRE consensus 2011:
- •At least two of the following three features must be present:
- •(i) Advanced maternal age (≥40 years) or any other risk factor for POR; (ii) A previous POR (≤3 oocytes with a conventional stimulation protocol); (iii) An abnormal ovarian reserve test (i.e. AFC ,5-7 follicles or AMH ,0.5 -1.1 ng/ml).
排除标准
- •women who suffer from any other cause of infertility other than poor ovarian reserve
- •refusal of the patient to consent for using her data in the study.
研究组 & 干预措施
Microflare and growth hormone
the patients in this group were given oral contraceptive pills (OCPs) for 28 days, this was followed by 2 days free. Triptorelin (Decapeptyl Ferring Pharmaceuticals, Germany) 0.05 mg/day S.C. was then started daily followed by human menopausal gonadotropin IM daily (HMG 75 IU, Merional, IBSA) 3 days later. Growth hormone (Norditropin, Novo nordisk) was administrated on day 6 of HMG stimulation daily in a dose of 2.5 mg S.C. till the day of hCG administration.
干预措施: Growth hormone (Norditropin, Novo nordisk) (Drug)
结局指标
主要结局
Clinical pregnancy rates
时间窗: 15 months
次要结局
未报告次要终点
研究者
Dina Mohamed Refaat Dakhly
Lecturer of obstetrics and gynecology
Woman's Health University Hospital, Egypt