NCT05832931已完成3 期
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Dose-Titrated PLS240 in the Treatment of Secondary Hyperparathyroidism in Individuals With End Stage Kidney Disease on Hemodialysis (PATH-1) With an Open-Label Extension
Pathalys Pharma68 个研究点 分布在 2 个国家目标入组 362 人开始时间: 2023年4月28日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 362
- 试验地点
- 68
- 主要终点
- Double-Blind Phase: Proportion of PLS240 treated participants compared to placebo treated participants with a ≥30% decrease in mean iPTH
研究概览
简要总结
This study is to evaluate the efficacy and safety of PLS240 in patients with hemodialysis-dependent end stage kidney disease (ESKD) and secondary hyperparathyroidism (SHPT). The study consists of two phases. First, a placebo-controlled, double-blind phase where patients will be randomly assigned to either receive dose-titrated PLS240 or matching placebo for 27 weeks. After the completion of the double-blind phase, patients will be eligible to enroll in the open-label extension phase, where they will receive dose-titrated PLS240 for an additional 26 weeks. Throughout the duration of the study, patients will be expected to attend multiple study visits where an investigator will collect blood, preform electrocardiograms (ECGs) and physical exams, and further assess the safety and efficacy of PLS240.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18 - 80 years at time of informed consent.
- •Prescribed hemodialysis for 3 times per week and on therapy for at least 3 months and has a delivered Kt/V≥1.2 within 4 weeks prior to signing the ICF.
- •Pre-dialysis central laboratory iPTH must be ≥400 pg/mL on at least two assessments performed at 2 visits, at least 1 week apart during the Active Screening period. iPTH may be tested up to 4 times.
- •at least performed at least a week after the previous iPTH.
- •Pre-dialysis central laboratory cCa must be ≥8.3 mg/dL on at least one assessment performed during the Active Screening period. cCa may be tested up to 3 times during the Active Screening period.
- •Dialysate calcium concentration ≥2.5 mEq/L (1.25 mmol/L) and stable for at least 4 weeks prior to signing the ICF.
- •Participants receiving active Vitamin D sterols (e.g., doxercalciferol or calcitriol) to manage SHPT must be on a stable dose (e.g., maximum dose change ≤50%), in the opinion of the investigator or sub-investigator, within the 2 months prior to signing the ICF, remain stable, as defined as no increase in dose, through the screening period, and be expected to maintain a stable dose, as defined as no increase in dose, for the duration of the study.
- •Participants receiving phosphate binders must be on a stable dose (e.g., maximum dose change ≤50%), in the opinion of the investigator or sub-investigator, within the 2 months prior to signing the ICF, remain stable through the screening period, and be expected to maintain stable dose for the duration of the study.
- •Participants receiving calcium supplements must be on a stable dose (e.g., maximum dose change ≤50%), in the opinion of the investigator or sub-investigator, within the 2 months prior to signing the ICF and remain stable through the screening period.
- •Female participants who are post-menopausal ('post-menopausal' women have had no menses for the previous year and are over the age of 50 years), or surgically sterilized, or have a medical condition that prevents pregnancy, or commit to remain abstinent during the study and for 2 weeks after the last dose of the investigational product (IP), or are willing to use highly effective contraception during the study and for 2 weeks after the last dose of IP. Women of child-bearing potential must have a negative serum pregnancy test during the screening period.
- •Male participants who are willing to use highly effective contraception when sexually active and will not donate sperm during the treatment phase and for 2 weeks after the last dose of IP.
- •Voluntarily given written informed consent to participate in this study.
- •Agrees to not participate in another study of an investigational agent during the study
- •To be eligible for inclusion into the Open-Label Extension Phase of the study, participants must fulfill the additional following criteria at the time of entry into the Open-Label Extension Phase:
- •Have successfully completed the course of treatment and final safety follow-up visit of the Double-Blind Phase.
- •Voluntarily given written informed consent to participate in the Open-Label Extension Phase of the study.
- •Prescribed hemodialysis for 3 times per week.
- •Continue to meet Inclusion Criteria 9, 10, and 12.
排除标准
- •Diagnosis of primary hyperparathyroidism.
- •Pre-dialysis central laboratory Active Screening iPTH >1500 pg/mL on two or more occasions. iPTH may be tested up to 4 times during the Active Screening period.
- •History of parathyroid intervention including parathyroidectomy (PTx) and percutaneous ethanol injection therapy (PEIT) within 26 weeks before signing the ICF.
- •Treatment with any prohibited medication as defined in Section 8.3.
- •Anticipated or scheduled parathyroidectomy during the study period.
- •Planned living-related or living-unrelated kidney transplant during the study period.
- •Change in mode of dialysis (e.g., from hemodialysis to hemodiafiltration, peritoneal dialysis to hemodialysis, at home to in center dialysis), dialysate Ca concentration, or prescribed dialysis treatment time within 4 weeks before signing the ICF.
- •Noncompliant with hemodialysis (i.e., missing more than 2 dialysis sessions within 8 weeks prior to signing the ICF, unless absence is due to hospitalization or dialysis-access procedures).
- •Clinically significant abnormalities on screening laboratory tests (may repeat abnormal laboratory tests) according to the Investigator including but not limited to the following:
- •Serum albumin ≤3.0 g/dL
- •Serum magnesium <1.5 mg/dL
- •Serum P >8.0 mg/dL
- •Hemoglobin <8.5 g/dL
- •Platelet count <100,000 x106/L
- •Serum transaminase (alanine transaminase [ALT] or serum glutamic pyruvic transaminase [SGPT], alanine transaminase [AST] or serum glutamic oxaloacetic transaminase [SGOT]) ≥2.5 times the upper limit of normal (ULN) during Active Screening.
- •Diagnosed with an unstable medical condition, defined as having been hospitalized, other than for dialysis vascular access intervention, within 30 days prior to signing the TCF, or otherwise unstable in the judgment of the investigator.
- •History of malignancy within the last 2 years prior to signing the ICF (except squamous or basal cell skin cancers, or cervical carcinoma in situ).
- •Recent history (within 4 weeks prior to signing the ICF) of angina pectoris with symptoms that occur at rest or minimal activity. Chest pain on dialysis (within 8 weeks prior to signing the ICF) unless evaluated by a cardiologist with documentation that the chest pain is not due to cardiac ischemia.
- •History of New York Heart Association (NYHA) Functional Class 3 or 4 heart failure.
- •History of myocardial infarction, coronary angioplasty, or coronary arterial bypass grafting within the past 4 months prior to signing the ICF.
- •Stroke (cerebral infarction or cerebral hemorrhage) within 6 months prior to signing the ICF.
- •Participant is receiving treatment for a seizure disorder or has a history of a seizure within 12 weeks prior to signing the ICF.
- •Poorly controlled diabetes mellitus, in the judgment of the investigator or sub-investigator.
- •Poorly controlled hypertension (defined as post-dialysis [seated if available] systolic pressure >180 mmHg or diastolic pressure >110 mmHg) at 2 or more dialysis sessions during the 2 weeks prior to signing the ICF.
- •Enrolled in other invasive investigational device or investigational drug trials, within at least 30 days prior to signing the ICF or are receiving other investigational agents (experimental dialysis machines are acceptable).
- •History of symptomatic ventricular dysrhythmias or Torsade de Pointes.
- •History of or family history of long QT syndrome.
- •QTcF >500 msec on screening ECG.
- •Pregnant or breast feeding.
- •Prior exposure or hypersensitivity to PLS240 or any of its components.
- •Current, recent, or suspected infection with SARS-CoV-2/COVID-19 within 4 weeks prior to signing the ICF.
- •In the opinion of the investigator, any disorder that would interfere with understanding and giving informed consent, or compliance with protocol requirements.
- •Participants must be excluded from the Open-Label Extension Phase of the study, in case of the following at the time of entry into the Open-Label Extension Phase:
- •In the opinion of the investigator, continuation into the Open-Label Extension Phase is not considered safe and/or feasible.
- •Continues to meet Exclusion Criterion #5.
研究组 & 干预措施
Double-Blind Phase PLS240
Experimental
干预措施: PLS240 (Drug)
Double-Blind Phase Placebo
Placebo Comparator
干预措施: Placebo (Drug)
Open-Label Extension Phase PLS240
Experimental
After completion of the Double-Blind Phase, all participants will have the opportunity to enroll in the 26 week Open-Label extension, where they will receive PLS240.
干预措施: Open-Label Extension PLS240 (Drug)
结局指标
主要结局
Double-Blind Phase: Proportion of PLS240 treated participants compared to placebo treated participants with a ≥30% decrease in mean iPTH
时间窗: each visit from screening through week 27
This measurement will be calculated based on the Efficacy Assessment Period (Weeks 22 - 27) relative to the mean baseline iPTH (all Active Screening and predose Day 1 iPTH values).
Open-Label Phase: Proportion of participants with a corrected serum calcium (cCa) <7.5 mg/dL
时间窗: up to week 28
Open-Label Phase: Number of Serious Adverse Events (SAEs)
时间窗: up to week 28
Open-Label Phase: Number of Adverse Events (AEs)
时间窗: up to week 28
Open-Label Phase: Proportion of participants with a corrected serum calcium (cCa) <8.3 mg/dL
时间窗: up to week 28
次要结局
未报告次要终点
研究者
研究点 (68)
Loading locations...
相似试验
已完成
3 期
Parathyroid Hormone (PTH) Attenuation Trial in Hemodialysis-2Secondary HyperparathyroidismEnd Stage Kidney DiseaseNCT05836220Pathalys Pharma412
已完成
3 期
Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat-Three-times Weekly Dosing in Dialysis (ASCEND-TD)AnaemiaNCT03400033GlaxoSmithKline407
Unknown
3 期
EPA-FFA to Treat Hospitalised Patients With COVID-19 (SARS-CoV-2)SARS-CoV-2NCT04335032S.L.A. Pharma AG284
已完成
3 期
AZD0585 Phase III Long-term Study in JapanHypertriglyceridemiaNCT02463071AstraZeneca383
已完成
3 期
Rituximab Plus Lenalidomide for Patients With Relapsed / Refractory Indolent Non-Hodgkin's Lymphoma (Follicular Lymphoma and Marginal Zone Lymphoma)Lymphoma, Non-HodgkinNCT01938001Celgene358