Evaluating the Efficacy of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 146
- 试验地点
- 1
- 主要终点
- the value of fractional exhaled nitric oxide(FeNO) in patients with cough variant asthma
研究概览
简要总结
The aim of the research is to evaluate the clinical value of fractional exhaled nitric oxide(FeNO) ,impulse oscillometry(IOS) and mid-expiratory flow (MEF) in patients with cough variant asthma.
详细描述
The present study has the following objectives:
to evaluate the relationship between BHR and mid-expiratory flow, to assess the diagnostic accuracy of fractional exhaled nitric oxide，impulse oscillometry and mid-expiratory flow in CVA with special regard to its discriminating value between CVA and other causes of a chronic cough, to estimate prognostic value of BHR and fractional exhaled nitric oxide (FeNO) count in predicting response to asthma treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18-65 years old. Cough as the sole or predominant symptom lasting for at least 8 weeks, with no radiographic evidence of lung diseases.
排除标准
- •treatment of any oral corticosteroid in the last 4 weeks, and respiratory tract infection within 8 weeks.
- •smoking (min. 6 months) had asthma or other lung diseases, including obliterative bronchiolitis, bronchiectasis,and cystic fibrosis.
结局指标
主要结局
the value of fractional exhaled nitric oxide(FeNO) in patients with cough variant asthma
时间窗: at least 4 weeks of treatment
FENO will be performed by using a hand-held portable machine (NIOX MINO, Aerocrine AB, Solna, Sweden) at a standard flow rate of 50 mL/s, in accordance with ATS/ERS recommendations.
the value of impulse oscillometry(IOS) in patients with cough variant asthma
时间窗: at least 4 weeks of treatment
R5-R20（respiratory resistance）is measure by Jaeger MasterScreen Pulmonary
次要结局
- the value of forced mid-expiratory flow (MMEF) in patients with cough variant asthma(at least 4 weeks of treatment)
- the value of BHR and fractional exhaled nitric oxide (FeNO) count in predicting response to asthma treatment(at least 4 weeks of treatment)
- the relationship between BHR and mid-expiratory flow(at least 4 weeks of treatment)