Efficacy of Adjunctive Photodynamic Therapy Using Light-emitting Diode in the Treatment of Chronic Periodontitis
试验速览
- 阶段
- 2 期
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Probing pocket depth
研究概览
简要总结
The aim of this randomized clinical trial is to clinically evaluate the effectiveness of the adjunctive use of photodynamic therapy (PDT) with an light-emitting diode (LED) light source in the treatment of chronic periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinically diagnosis of advanced chronic periodontitis with more than 3 mm clinical attachment loss
- •presence of at least two teeth with probing depth of 4 to 6 mm without furcation involvement in each quadrant
- •at least 16 remaining teeth
- •no periodontal treatment in the past 12 months
- •no evidence of systemic disease related to periodontal problems
- •no use of antibiotics for the past 6 months
- •No smoking more than 10 cigarettes per day
- •no addiction to any kind of drugs
- •no pregnancy
排除标准
- 未提供
研究组 & 干预措施
Photodynamic therapy
will be treated by PDT using Light-emitting diod(LED) (625-635nm,200mw/cm2 ,30 s for each site, fotoson CMS Dental ,Denmark) in the presence of toluidine blue O (TBO)
干预措施: Adjunctive Photodynamic Therapy (Other)
Light-emitting diode Irradiation
will be treated only by using Light-emitting diode(LED) (625-635nm,200mw/cm2 ,30 s for each site, fotoson CMS Dental ,Denmark)
干预措施: Light-emitting diod Irradiation (Other)
applying photosensitizer
will be treated only by toluidine blue O
干预措施: applying Photosensitizer (Other)
结局指标
主要结局
Probing pocket depth
时间窗: Baseline, one month, three month
distance from gingival margin to base of the clinical pocket by William's periodontal probe
次要结局
- Clinical attachment loss(Baseline, one month, three month)
- Bleeding upon probing(Baseline, one month, three month)
- plaque index(Baseline,before PDT procedure, one month, three month)