NCT04115059终止1 期
Dasatinib in Patients With Waldenström Macroglobulinemia (WM) Progressing on Ibrutinib
Jorge J. Castillo, MD1 个研究点 分布在 1 个国家目标入组 3 人开始时间: 2019年11月4日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 发起方
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- Number of Participants With at Least One Treatment-Emergent Adverse Event
研究概览
简要总结
This is Phase I pilot, single center study designed to explore the safety of Dasatinib in symptomatic Waldenström Macroglobulinemia participants who are progressing on ibrutinib therapy with BTK Cys481 or PLCG2 mutations
详细描述
This research study is a Pilot Study, which is the first time investigators are examining this drug in patients with Waldenström Macroglobulinemia who have progressed on ibrutinib.
Patients who fulfill eligibility criteria will be entered into the trial to receive Dasatinib
After the screening procedures confirm participation in the research study:
The participant will be given a study drug-dosing calendar for each treatment cycle. In this research study, the investigators are planning to give Dasatinib, which is a targeted therapy intended to treat cancer by binding to the target protein called BTK.
- BTK is believed to be an important target for treatment of patients with specific gene mutations. Some patients who have disease progression after taking ibrutinib have these gene mutations.
- Making treatment decisions based on genetic testing is investigational, and the FDA has not approved this genetic testing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants must meet the following criteria on screening examination to be eligible to participate. Screening evaluations including consent, physical exam, and laboratory assessments will be done within 30 days prior to Cycle 1 Day
- •Bone marrow biopsy & aspirate, and CT C/A/P will be done within 90 days prior to Cycle 1 Day
- •Clinicopathological diagnosis of Waldenstrom's Macroglobulinemia
- •Known tumor expression of mutated MYD88 performed by a CLIA certified laboratory.
- •Participants must have a BTKCys481 and/or PLCγ2 mutation. Genomic alterations must be confirmed via sequencing performed at NeoGenomics Laboratories
- •At least one previous therapy, with ibrutinib as the most recent treatment. Participants may remain on ibrutinib therapy during screening. A 1 day washout before starting dasatinib is required.
- •Documented disease progression on last regimen (ibrutinib) per the Sixth International Workshop on WM. One or more of the following:
- •25% increase in serum IgM level with at least 500 mg/dL absolute increase from nadir with re-confirmation
- •Progression of clinically significant disease related symptoms
- •Symptomatic disease meeting criteria for treatment using consensus panel criteria from the Second International Workshop on WM [26]. One or more of the following:
- •Constitutional symptoms
- •Progressive or symptomatic lymphadenopathy or splenomegaly
- •Hemoglobin <10 g/dL
- •Platelet count <100 k/uL
- •Symptomatic peripheral neuropathy
- •Systemic amyloidosis
- •Renal insufficiency
- •Symptomatic cryoglobulinemia
- •Age 18 years or older
- •Measurable disease, defined as presence of immunoglobulin M (IgM) paraprotein with a minimum serum IgM level of > 2 times the upper limit normal.
- •ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)
- •Women of childbearing potential: Females of childbearing potential (FCBP) must agree to use two reliable forms of contraception simultaneously or have or will have complete abstinence from heterosexual intercourse during the following time periods related to this study: 1) while participating in the study; and 2) for at least 28 days after discontinuation from the study. FCBP must be referred to a qualified provider of contraceptive methods if needed.
- •Men must agree to use a latex condom during sexual contact with a female of childbearing potential (FCBP) even if they have had a successful vasectomy.
- •Participants must have normal organ and marrow function as defined below:
- •Absolute neutrophil count ≥500/ uL (Growth factor not permitted)
- •Platelets ≥50,000/ uL (Platelet transfusion not permitted)
- •Hemoglobin ≥ 7 g/dL (RBC transfusion permitted)
- •Total bilirubin ≤ 2 mg/dL
- •Potassium ≥ LLN
- •Magnesium ≥ LLN
- •AST(SGOT)/ALT(SGPT) ≤2.5 × institutional upper limit of normal
- •Estimated GFR ≥ 30 ml/min
- •Able to swallow pills.
- •Able to adhere to the study visit schedule and other protocol requirements.
- •Ability to understand and the willingness to sign a written informed consent document.
排除标准
- •Participants who exhibit any of the following conditions at screening will not be eligible for admission into the study:
- •Lactating or pregnant women.
- •Participants who are receiving any other investigational agents.
- •Prior therapy with BCR-ABL inhibitors.
- •Known CNS lymphoma.
- •Symptomatic hyperviscosity requiring urgent therapy.
- •Human Immunodeficiency Virus (HIV), active infection with Hepatitis B Virus (HBV), and/or Hepatitis C Virus (HCV).
- •Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, pleural or pericardial effusion, unstable angina pectoris, cardiac arrhythmia, QT Prolongation, or psychiatric illness/social situations that would limit compliance with study requirements.
- •Prolonged QTc interval on pre-entry electrocardiogram (> 450 msec)
- •History clinically significant ventricular arrhythmias such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes
- •Known history of alcohol or drug abuse
- •On any active therapy for other malignancies with the exception of topical therapies for basal cell or squamous cell cancers of the skin.
- •History of non-compliance to medical regimens.
- •Treatment with strong CYP3A4/5 inhibitors or inducers
- •Participants who are taking St. Johns Wort. Must discontinue at least 5 days before starting dasatinib.
- •Treatment with H2 Antagonists and proton pump inhibitors
研究组 & 干预措施
Dasatinib
Experimental
-- After the screening procedures confirm participation in the research study: The participant will be given a study drug-dosing calendar for each treatment cycle.
Dasatinib: Oral Study Drug(s):
- Each study treatment cycle lasts 4 weeks during which time you will be taking the study drug one time per day.
- This will continue for up to 24 cycles.
干预措施: Dasatinib (Drug)
结局指标
主要结局
Number of Participants With at Least One Treatment-Emergent Adverse Event
时间窗: 2 years
Count of participants who experience a treatment-emergent adverse event
次要结局
- Minimal Response Rate(2 years)
- Partial Response Rate(2 years)
- Overall Response Rate(2 years)
- Time to Next Therapy (TTNT)(From first dose through initiation of new therapy, up to 2 years from baseline)
- Very Good Partial Response Rate(2 years)
- Stable Disease Rate(2 years)
- Complete Response Rate(2 years)
- Progressive Disease Rate(From first dose through disease progression, up to 2 years from baseline)
- Progression Free Survival(From first dose through disease progression, up to 2 years from baseline)
- Overall Survival(From first dose through death, up to 2 years from baseline)
研究者
Jorge J. Castillo, MD
Sponsor Investigator
Dana-Farber Cancer Institute
研究点 (1)
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