Concentration of S-1 Metabolites in Tear and Plasma and Correlation With Its Side Effects in Patients Receiving S-1 Adjuvant Chemotherapy
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
研究概览
简要总结
S-1 has been also shown to be an effective drug for palliative chemotherapy in Eastern and Western GC patients. Recently, some case and small-sized studies have been reported on lacrimal drainage obstruction(LDO)caused by S-1.Suggested mechanism of LDO involves direct secretion of S-1 into the tear; thus the concentration of S-1 metabolite in tear is expected to be high in patients who developed LDO than in patients without LDO. We investigate the concentration of S-1 and its metabolites in tear and plasma and find out its correlation with side effects such as LDO. These results will also help us identify patients who are at high risk of developing S-1-associated side effects.
详细描述
-
S-1 metabolites concentration in plasma
-
factors affecting plasma concentration
- surgery subtype
- serum creatinine
- systemic adverse effects of S-1 and its correlation with plasma S-1 metabolites concentration
- enteritis
- fatigue
-
S-1 metabolites concentration in tears
-
correlation of tear concentration with plasma concentration
-
lacrimal drainage obstruction caused by S-1 administration, and its correlation with tear S-1 metabolites concentration
-
lacrimal drainage obstruction caused by S-1 administration, and its correlation with plasma S-1 metabolites concentration
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who received radical surgery for gastric cancer
- •Patients who receiving S-1 adjuvant chemotherapy
- •Patients who administrated S-1 for more than 7 days
排除标准
- •who using eyedrop medication
- •who has dry eye that tear cannot be sampled
研究者
Namju Kim
Professor for clinical department
Seoul National University Bundang Hospital