NCT01606605已完成不适用
Retrospective Analysis of Diffuse Large B-cell Lymphoma: Identification of Factors Associated With Treatment Resistance Via Gene Expression Profile
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Number of patients who relapse or progress after 1st line chemotherapy
研究概览
简要总结
The investigators perform a retrospective microarray gene expression profiling study of FFPE from a cohort of DLBCL patients with whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay. The investigators also study the pattern of microRNA from patients with diffuse large B-cell lymphoma. The results of gene expression profiles and microRNA is correlated with clinical outcomes of diffuse large B-cell lymphoma.
详细描述
- Whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay
- Diffuse large B-cell lymphoma patients
- Paraffin-embedded tissue
- End points: Progression-free survival, overall survival
- Statistics: Leave one-out method
- Nano string assay for microRNA
- Diffuse large B-cell lymphoma patients
- Paraffin-embedded tissue
- End points: Progression-free survival, overall survival
- Statistics: Leave one-out method
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 90 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with diffuse large B-cell lymphoma
- •Patients with tissue blocks available for study
- •Patients with adequate medical records
排除标准
- •Patients diagnosed with other subtypes of lymphoma
结局指标
主要结局
Number of patients who relapse or progress after 1st line chemotherapy
时间窗: two years
次要结局
- Number and type of genes and microRNA which are significantly related with relapse or progression (P < 0.05)(two years)
研究者
Won Seog Kim
Professor
Samsung Medical Center
研究点 (1)
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