Hepatobiliary Manifestations Following Two-Stages Elective Laparoscopic Restorative Proctocolectomy for Patients With Ulcerative Colitis. A Prospective Observational Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 167
- 主要终点
- severity of hepatobiliary manifestations after colectomy
研究概览
简要总结
Several studies using different methodological approach have revealed incomplete, old and conflicting data on the course of hepatobiliary manifestations after surgery. authors conducted a prospective observational study to evaluate the role of LRP on the course of hepatobiliary manifestations for a better knowledge of these manifestations that is necessary to improve their management.also, to evaluate the role of surgery on prevention of liver damage from progression of the disease.
详细描述
Inflammatory bowel disease (IBD) prevalence is expected to reach 1% of the population in many regions over the next decade. despite the fact that the primary clinical manifestations of IBD are centred in the gastrointestinal tract, 25-40% of IBD patients develop at least one extraintestinal manifestation (EIM).
Hepatobiliary manifestations constitute one of the most common EIMs in IBD . Hepatobiliary manifestations are much more commonly associated with ulcerative colitis (UC) and include primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH), fatty liver, cholelithiasis, primary biliary cholangitis, portal vein thrombosis, and hepatic abscess.
Most UC patients can be managed medically, but a minority requires proctocolectomy. Two-stage laparoscopic proctocolectomy (LPC) with ileal pouch-anal anastomosis (IPAA) is a cure for colitis, but its effect on hepatobiliary diseases is controversial.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients between 18-69 years,
- •both sex diagnosed as ulcerative colitis with at least one hepatobiliary manifestation
- •underwent laparoscopic restorative proctocolectomy with ileal pouch anal anastomosis
- •with or without gallstones.
排除标准
- •age<18 years or > 69 years,
- •alcohol abuse,
- •pregnancy,
- •severe heart failure or type II diabetes mellitus (defined as established diagnosis, HbA1c > 6.4%, non-fasting glucose level > 180 mg/dL, or on antidiabetic medication),
- •development of complications or death related to the operation of LRP ,
- •liver toxicity of IBD-related medications.,
- •chronic viral hepatitis,
- •haemochromatosis,
- •Wilson's disease,
结局指标
主要结局
severity of hepatobiliary manifestations after colectomy
时间窗: 4 years
severity of hepatobiliary manifestations are measured by abdominal ultrasonography,liver biopsy ,CT and MRCP
次要结局
未报告次要终点
研究者
Tamer.A.A.M.Habeeb
assistant professour of general and laparoscopic surgery
Zagazig University