NL-OMON40127已完成不适用
Effects of alpha-linolenic acid on 24h-ambulatory mean arterial pressure in untreated high-normal and stage I hypertensive subjects - VASALA study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 144
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Aged between 40-70 years
- •- Quetelet-index between 25-35 kg/m2
- •- High-normal blood pressure or stage I hypertension
- •- Mean serum total cholesterol < 8.0 mmol/L
- •- Mean serum triacylglycerol < 4.5 mmol/L
- •- Mean plasma glucose < 7.0 mmol/L
排除标准
- •- Unstable body weight (weight gain or loss >2 kg in the past 3 months)
- •- Use of antihypertensive or anticoagulant medication
- •- Indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus
- •- Usage of non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen) and not able or willing to stop taking them from at least 4 weeks prior to the study
- •- Use of medication or a diet known to affect serum lipid or glucose metabolism
- •- Women taking oral contraceptives or estrogen replacement therapy
- •- Women lactating, pregnant or intend to become pregnant during study
- •- Active cardiovascular disease like congestive heart failure or recent (<6 months) event (acute myocardial infarction, cerebro vascular accident)
- •- Severe medical conditions that might interfere with the study such as diabetes mellitus, epilepsy, asthma, chronic obstructive pulmonary disease, inflammatory bowel diseases and rheumatoid arthritis
- •- Abuse of drugs
- •- More than 21 alcohol consumptions per week for men and 14 consumptions for women
- •- Reported intense sporting activities > 10 h/w
- •- Not possible or difficult to venipuncture as evidenced during the screening visits
- •- Use of an investigational product within the previous 30 days
- •- Not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in plant stanol or sterol esters 3 weeks before the start of the study
- •- Not willing to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study and during the study
研究者
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