Foundational Work for a Brain-to-Society Diagnostic for Prevention of Childhood Obesity and Its Chronic Diseases Consequences
试验速览
- 阶段
- 不适用
- 入组人数
- 1,224
- 试验地点
- 2
- 主要终点
- Individual-level BtS Diagnostic 1
研究概览
简要总结
This multi-national program applies a breakthrough approach to childhood obesity called, Brain-to-Society (BtS) Diagnostic Approach. In Montreal, Canada and Palwal, India, the investigators will recruit two cohorts of 612 children (6 to 12 years; 306 boy/306 girls) where Whole-of-Society (WoS) transformations are taking place (industrialized societal context with peaking childhood obesity and where a broad governmental plan to promote healthy lifestyle has been adopted -Canada; developing societal context with increasing childhood obesity if replication of past pathways that have lead to double burden; India) are taking place along with World Health Assembly (WHA) resolution A63-12 for marketing of food to children. Individual-level BtS Diagnostic will examine the degree to which individual differences in genetics and biology and differences in the environmental exposures modulate the behavioral, body weight/fatness and nutritional risk over time in the context of WoS transformations. Societal-level BtS Diagnostic shall examine the influence of decisions in policy, investment, business and innovation made by different stakeholders (government, private sector, civil society in health and non-health society systems including agriculture, business and media practices) on the community.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 12 Years(Child)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sample population that are exposed to multi-level Whole-of-Society transformation (i.e., Quebec Governmental Action Plan (PAG) and World Health Assembly (WHA) resolution for Quebec sample; Intense Urbanization and Industrialization (IUI) and WHA resolution in India).
排除标准
- •first cousin relations were excluded from the sample population.
结局指标
主要结局
Individual-level BtS Diagnostic 1
时间窗: 2 years
Genotyping and detection of the Taq1A allele in the dopamine-2 receptor (DRD2) gene.
Individual-level BtS Diagnostic 2
时间窗: 2 years
Genotyping and detection of the exon 3 7-repeat allele of the dopamine-4 receptor (DRD4) gene.
次要结局
- Behavioral Assessment(2 years)
- Nutritional Risk Assessment(2 years)
- Body Weight Assessment(2 years)
