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临床试验/NCT03151694
NCT03151694Unknown不适用

Foundational Work for a Brain-to-Society Diagnostic for Prevention of Childhood Obesity and Its Chronic Diseases Consequences

McGill University2 个研究点 分布在 2 个国家目标入组 1,224 人开始时间: 2011年2月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
1,224
试验地点
2
主要终点
Individual-level BtS Diagnostic 1

研究概览

简要总结

This multi-national program applies a breakthrough approach to childhood obesity called, Brain-to-Society (BtS) Diagnostic Approach. In Montreal, Canada and Palwal, India, the investigators will recruit two cohorts of 612 children (6 to 12 years; 306 boy/306 girls) where Whole-of-Society (WoS) transformations are taking place (industrialized societal context with peaking childhood obesity and where a broad governmental plan to promote healthy lifestyle has been adopted -Canada; developing societal context with increasing childhood obesity if replication of past pathways that have lead to double burden; India) are taking place along with World Health Assembly (WHA) resolution A63-12 for marketing of food to children. Individual-level BtS Diagnostic will examine the degree to which individual differences in genetics and biology and differences in the environmental exposures modulate the behavioral, body weight/fatness and nutritional risk over time in the context of WoS transformations. Societal-level BtS Diagnostic shall examine the influence of decisions in policy, investment, business and innovation made by different stakeholders (government, private sector, civil society in health and non-health society systems including agriculture, business and media practices) on the community.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
6 Years 至 12 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Sample population that are exposed to multi-level Whole-of-Society transformation (i.e., Quebec Governmental Action Plan (PAG) and World Health Assembly (WHA) resolution for Quebec sample; Intense Urbanization and Industrialization (IUI) and WHA resolution in India).

排除标准

  • first cousin relations were excluded from the sample population.

结局指标

主要结局

Individual-level BtS Diagnostic 1

时间窗: 2 years

Genotyping and detection of the Taq1A allele in the dopamine-2 receptor (DRD2) gene.

Individual-level BtS Diagnostic 2

时间窗: 2 years

Genotyping and detection of the exon 3 7-repeat allele of the dopamine-4 receptor (DRD4) gene.

次要结局

  • Behavioral Assessment(2 years)
  • Nutritional Risk Assessment(2 years)
  • Body Weight Assessment(2 years)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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