Effect of Intraoperative Tetracycline on Postoperative Pain After Mandibular Molar Extraction: A Randomized Controlled Trial

Surgical extraction of mandibular molars is one of the most frequently performed procedures in oral and maxillofacial surgery and is commonly associated with postoperative pain, inflammation, and delayed patient recovery. The intensity of postoperative pain is influenced by tissue trauma, inflammatory mediator release, and bacterial colonization of the extraction socket. Although systemic analgesics are routinely prescribed to control postoperative pain, their prolonged use may be associated with adverse effects. Therefore, adjunctive local therapies that can reduce postoperative pain while minimizing systemic medication use are of clinical interest.

Tetracycline is a broad-spectrum antibiotic with additional anti-inflammatory properties. Besides inhibiting bacterial protein synthesis, tetracycline suppresses matrix metalloproteinases, reduces inflammatory cytokine activity, and promotes wound healing. Local application of tetracycline directly into the extraction socket may provide sustained antimicrobial and anti-inflammatory effects at the surgical site, thereby reducing postoperative pain without increasing systemic drug exposure.

Previous clinical studies have reported beneficial effects of locally applied tetracycline in reducing postoperative pain and improving socket healing following dental extractions. However, evidence from the local population remains limited. Differences in patient characteristics, surgical techniques, and healthcare settings necessitate evaluation of this intervention within the Pakistani population.

This study is designed as a prospective, parallel-group, randomized controlled trial conducted at the Department of Oral and Maxillofacial Surgery, CMH Lahore Medical College and Institute of Dentistry, Lahore. Seventy-four patients requiring surgical extraction of mandibular molars will be enrolled after providing written informed consent. Participants will be randomly allocated in a 1:1 ratio to either the intervention group or the control group.

Participants in the intervention group will receive 250 mg tetracycline mixed with 0.5 mL sterile saline and placed directly into the extraction socket before wound closure. Participants in the control group will undergo the same surgical procedure without placement of any intrasocket medicament. All surgical procedures will be performed by the same surgeon using a standardized surgical protocol. Postoperative management, including analgesics and oral hygiene instructions, will be identical for both groups.