A randomized, multicenter, international, open-label study of infliximab plus methotrexate versus methotrexate (MTX) alone for the treatment of MTX naïve subjects with Active Psoriatic Arthritis

Integrated Therapeutics Group, Inc. - A subsidiary of Schering-Plough Corp.0 个研究点目标入组 216 人开始时间: 2006年1月3日最近更新: 2019年6月30日

适应症

试验速览

阶段: 1 期
状态: 进行中（未招募）
发起方
入组人数: 216

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

暂无简介。

研究设计

研究类型: Interventional clinical trial of medicinal product

入排标准

性别: All

入选标准

•The subject must meet ALL of the criteria listed below for entry into the study:
•1)Subject must demonstrate their willingness to participate in the study and comply with its procedures by signing a written informed consent.
•2)Subject aged 18 years or more, of either sex and any race
•3)Diagnosis of Psoriatic Arthritis with peripheral polyarticular involvement.
•Patients will have at least one of the following:
•i.DIP involvement
•ii.polyarticular arthritis, absence of rheumatoid nodules and presence of psoriasis
•iii.arthritis mutilans
•iv.asymmetric peripheral arthritis
•4)Negative rheumatoid factor
•5)The disease should have been diagnosed at least 3 months prior to screening.
•6)Active disease at the time of screening and prior to receiving the baseline study medication(s) as defined by:
•i.5 or more swollen joints and
•ii.5 or more tender joints
•iii.and one out of the following three categories:
•ESR = 28 mm/h
•CRP = 15 mg/l
•Morning stiffness = 45 min
•7)Subjects must confirm that they are practicing adequate contraception:
•Female subjects of childbearing potential (includes women who are less than 1 year postmenopausal and women who become sexually active during the study) must agree to use a medically accepted method of contraception or be surgically sterilized prior to screening, while receiving protocol-specified medication, and for 6 months after stopping the medication.
•Acceptable methods of contraception include condoms (male and female) with or without a spermicidal agent, diaphragm or cervical cap with spermicide, medically prescribed IUD, oral or injectable hormonal contraceptive, and surgical sterilization (eg, hysterectomy or tubal ligation).
•8)Female subjects of childbearing potential must have a negative pregnancy test at Screening.
•9)Subjects must be eligible for anti-TNF treatment according to applicable local guidelines. For all patients chest X-ray and skin test results must be available at baseline.
•10)If using NSAIDs or corticosteroids other than i.v., i.m. or i.a. the patient must be on a stable dose for two weeks prior screening (maximum dose up to 10 mg/day of prednisone, or its oral equivalent).
•11)The screening laboratory tests must meet the following criteria:
•i.Hemoglobin = 10 g/dl providing the low hemoglobin level is not due to other diseases than anemia of chronic inflammation.
•ii.WBC = 3500 / µl
•iii.Neutrophils = 1500 / µl
•iv.Platelets = 100 000 / µl
•v.Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and gamma-glutamyltransferase =1.5 x upper limit of normal
•vi.Total bilirubin = 1 x upper limit of normal
•vii.Serum creatinine = 1.5 mg/dl
•12)Patient must be able to adhere to the study visit schedule and other protocol requirements and must have given informed consent prior to any screening procedures.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

排除标准

•The subject will be excluded from entry into the study if ANY of the criteria listed below are met.
•1)Subject is a female who is pregnant, intends to become pregnant during the study (or within 6 months after study completion), or nursing.
•2)Patients with other inflammatory diseases that might interfere with the evaluation of the psoriatic arthritis.
•3)Previous treatment with Infliximab
•4)Subjects who have previously received MTX or have not discontinued their other DMARD therapy (i.e. sulfasalazine, hydroxychloroquine, leflunomide).
•5)Patients with fibromyalgia syndrome.
•6)Use of cyclosporine or tacrolimus within 4 weeks prior to screening. Use of IM, IV, or IA corticosteroids within 4 weeks prior to screening.
•7)Treatment with any investigational drug within 3 months prior to screening.
•8)Previous treatment with a monoclonal antibody or a fusion protein.
•9)A history of known allergy to murine proteins.
•10)History of infected joint prosthesis within the previous 5 years.
•11)Chronic infections.
•12)History of active tuberculosis requiring treatment within previous 3 years, or history of opportunistic infections within 2 months, uncontrolled active infection or documented HIV infection. Also excluded are patients with evidence of latent tuberculosis and patients with old tuberculosis without documented adequate therapy if they will not be treated according to local TB guidelines.
•13)Subject has any clinically significant deviation from normal in the physical examination, Chest X-ray, or ECG that, in the investigator’s judgment, may interfere with the study evaluation or affect subject safety.
•14)Current signs or symptoms of other severe uncontrolled diseases which in the investigators opinion would put the patient at an unacceptable risk.
•15)History of lymphoproliferative disease, any current malignancies or history of malignancy within 5 years other than successfully treated basal cell carcinoma or squamous cell carcinoma of the skin.
•16)Subject is part of the staff or a family member of the staff personnel directly involved with this study.
•17)History of drug abuse.
•18)Subjects who are participating in any other clinical study.

研究者

发起方

Integrated Therapeutics Group, Inc. - A subsidiary of Schering-Plough Corp.

相似试验

进行中（未招募）

不适用

EUCTR2005-002189-12-EESchering Plough Research Institute216

进行中（未招募）

1 期

EUCTR2005-002189-12-LTIntegrated Therapeutics Group, Inc. - A subsidiary of Schering-Plough Corp.216

进行中（未招募）

1 期

EUCTR2005-002189-12-SIIntegrated Therapeutics Group, Inc. - A subsidiary of Schering-Plough Corp.216

进行中（未招募）

1 期

EUCTR2005-002189-12-LVIntegrated Therapeutics Group, Inc. - A subsidiary of Schering-Plough Corp.216

进行中（未招募）

1 期

A randomized, multicenter, international, open-label study of infliximab plus methotrexate versus methotrexate (MTX) alone for the treatment of MTX naïve subjects with Active Psoriatic Arthritis Randomizované, multicentrické, medzinárodné, otvorené klinické skúšanie infliximabu a metotrexátu oproti metotrexátu (MTX) samotnému v liecbe aktívnej psoriatickej artritídy u pacientov ešte neliecených metotrexátom. - Infliximab + MTX vs. MTX alone in PsA.Pacienti s aktívnou psoriatickou artiritídou.MedDRA version: 8.0 Level: PT Classification code 10037161

EUCTR2005-002189-12-SKIntegrated Therapeutics Group, Inc. - A subsidiary of Schering-Plough Corp.216