Antithrombotic Drug Use in Patients With Ischemic Stroke and Microbleeds
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3,000
- 试验地点
- 23
- 主要终点
- Increase of cerebral microbleeds
研究概览
简要总结
To observe the effect of different antithrombotic drugs on the prognosis of ischemic stroke patients with cerebral microbleeds. And further combined with proteomic methods to explore serological markers that can be used to accurately predict the prognosis of such patients.
详细描述
Cerebral microbleeds (CMBs) are caused by microvascular lesions in the brain, which is a subclinical deposition of hemosiderin after the damage of microvascular. Antithrombotic drug are widely used in the secondary prevention of patients with ischemic stroke. Studies have shown that antithrombotic drug can increase the incidence of intracranial hemorrhage in ischemic stroke patients with cerebral microbleeds. For such patients, how to carry out effective and safe antithrombotic therapy is still unclear.
We will study from two aspects: 1) We designed a cohort registration study to observe the prognosis and progress of CMBs in ischemic stroke patients one year after using various antithrombotic drugs. 2) Data independent acquisition quantitative proteomics (DIA quantitative proteomics) will be used to screen serum protein markers that may affect the prognosis of ischemic stroke patients with CMBs.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed clinically as ischemic stroke;
- •Age ≥ 40 years;
- •Onset time ≤ 3 months;
- •Informed consent was signed.
排除标准
- •Patients with symptomatic intracranial hemorrhage;
- •bleeding lesion > 10 mm was found on SWI;
- •Vascular malformations, tumors, abscesses or other major non ischemic brain diseases were present;
- •There are contraindications for antithrombotic drugs use;
- •Serious systemic diseases;
- •Refusal to sign informed consent or poor compliance.
结局指标
主要结局
Increase of cerebral microbleeds
时间窗: 1 year after onset
How many cerebral microbleeds increased after 1 year of antithrombotic drugs treatment. The number of microbleeds will be detected by MR-SWI.
次要结局
- Stroke recurrence rate(1 year after onset)
- The incidence of cerebral hemorrhage(1 year after onset)