tDCS Stimulation Combined With VI as a Possible Therapy for Enhancing Functional Ability in SCI With Neuropathic Pain
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 主要终点
- change in SCIM 3 (scale)
研究概览
简要总结
Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) will be applied for patient who suffer from neuropathic pain following spinal cord injury The tDCS treatment will be coupled with a video of a man walking (creating a visual illusion) in order to enhance functional ability and reduce pain
详细描述
Non-invasive cortical brain stimulation is a promising method for treating cases of neuropathic pain in patients with spinal cord injury (SCI). Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) appears to modulate cortical excitability and can reduce pain levels following SCI, however its effects remaining for short-term and may not be useful for the rehabilitation progress in these patients.
Recent findings suggest that M1 stimulation combined with visual illusion (VI) enhances the reduction in pain which maintain up to 3 month following treatment. The current study aims to reveal whether reduction of neuropathic pain in patients with SCI through tDCS have beneficial effect on functional ability during rehabilitation program.
In the present study the investigators will use anodal stimulation of the M1 via neuroConn DC stimulator. Current intensity of 2mA or sham stimulation will be given during 20 min in parallel to a visual illusion of walking legs (or neutral video for sham stimuli).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients hospitalized in spinal cord rehabilitation department
- •neuropathic pain following spinal cord injury
- •able to seat on a wheel chair
- •able to understand and comply with basic instructions
- •Hebrew speakers
排除标准
- •non-neuropathic pain
- •medical condition that affect cognitive functioning
- •medical condition other then the spinal cord injury that affect functioning
结局指标
主要结局
change in SCIM 3 (scale)
时间窗: up to 7 day before and following the treatment
spinal cord independence measure
次要结局
- change in VAS (Visual Analog Scale)(up to 7 day before and following the treatment)
- change in BPI (Brief Pain Inventory)(up to 24h before and following the treatment)
研究者
motti ratmansky
Director, Pain Unit
Loewenstein Hospital