An Investigation of the Effects of Opioid Receptor Blockade on Changes in Self-esteem and Attentional Bias Toward Social Cues
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 主要终点
- Self-esteem
研究概览
简要总结
The purpose of this study is to explore the effects of endogenous opioids on self-esteem and attentional bias toward social cues. This is achieved by administering the drug naltrexone, which temporarily decreases endogenous opioid activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •good physical health,
- •normal kidney and liver function results from within previous year
排除标准
- •allergy to naltrexone
- •kidney or liver injury or disorder
- •bipolar, panic, or psychotic disorders
- •smoking more than 15 cigarettes per day
- •pregnancy
- •substance abuse
- •use of opioid analgesics, cocaine, recreational drugs (e.g., marijuana, LSD, ecstasy, etc.), or prescription medication (except oral contraceptives) within the past 10 days
- •use of over-the-counter drugs (e.g., analgesics, anti-inflammatories, sleeping aids, etc.) or alcohol within the past 24 hours
- •current experience of pain (e.g., headache)
- •use of anti-diarrheal medications in the 7 days prior to the study.
研究组 & 干预措施
Placebo
cellulose-filled capsule
干预措施: Placebo (Drug)
Naltrexone
single 50 mg oral dose naltrexone (capsule)
干预措施: Naltrexone (Drug)
结局指标
主要结局
Self-esteem
时间窗: Approximately 2 hours post placebo/drug administration
Self-reported levels of self-esteem assessed using the Rosenberg Self-Esteem Scale (Rosenberg, 1965). Possible scores range from 1 to 4. Higher scores indicate higher levels of self-esteem.
Attentional bias scores for positive social cues on visual probe task
时间窗: Approximately 2 hours post placebo/drug administration
Attentional bias was assessed using a Visual Probe Task. The investigators used a version of the VPT (DeWall, Maner, \& Rouby, 2009) designed to assess attentional bias to cues of social acceptance (i.e., smiles). The outcome measure was attentional bias scores, calculated by subtracting mean reaction time scores on "valid" trials from mean reaction time on "invalid" trials. Higher positive scores indicate greater attentional bias to accepting faces.
次要结局
- Self-competence(Approximately 2 hours post placebo/drug administration)
- Attentional bias scores for negative social cues on visual probe task(Approximately 2 hours post placebo/drug administration)
- Reaction times on neutral-neutral trials on visual probe task(Approximately 2 hours post placebo/drug administration)
- Self-liking(Approximately 2 hours post placebo/drug administration)
研究者
Jennifer Bartz
Professor
McGill University