Synaptic Density in Psychiatric Disorders Using SV2A Receptor PET Imaging With [11C]APP311
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 250
- 试验地点
- 2
- 主要终点
- Synaptic density in psychiatric disorders using SV2A receptor PET Imaging with [11C]APP311
研究概览
简要总结
The aim of this study is to evaluate a new SV2A tracer, [11C]APP311, in healthy aging and neuropsychiatric disorders including psychotic disorders and cannabis use disorders.
详细描述
The overall goal of this protocol is to study synaptic density in two psychiatric disorders (namely schizophrenia and other psychotic disorders, and cannabis use disorder) with this exciting new PET tracer. Secondary outcomes will include electroencephalography (EEG). A battery of EEG paradigms assessing sensory, perceptual, and cognitive functions will also be administered. The primary dependent measures will be traditional event related potentials (ERPs; e.g. latency and amplitude) as well as time X frequency analysis (inter-trial coherence and spectral power).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Willing and able to give voluntary written informed consent
- •Male and Female subjects, age 18 to 65 years, inclusive
排除标准
- •MRI metal exclusions and claustrophobia.
- •Education completed is less than 12 years
研究组 & 干预措施
Schizophrenia and other psychotic disorders
For each [11C]APP311 PET scan, up to 20 mCi of [11C]APP311 will be administered by infusion pump, followed by up to 120 minutes of dynamic PET data acquisition.
干预措施: [11C]APP311 (Drug)
Cannabis Use Disorder
For each [11C]APP311 PET scan, up to 20 mCi of [11C]APP311 will be administered by infusion pump, followed by up to 120 minutes of dynamic PET data acquisition.
干预措施: [11C]APP311 (Drug)
Healthy Control
For each [11C]APP311 PET scan, up to 20 mCi of [11C]APP311 will be administered by infusion pump, followed by up to 120 minutes of dynamic PET data acquisition.
干预措施: [11C]APP311 (Drug)
结局指标
主要结局
Synaptic density in psychiatric disorders using SV2A receptor PET Imaging with [11C]APP311
时间窗: One test day (one time point).
To compare synaptic vesicle protein 2A (SV2A) density in two groups of subjects with psychiatric disorders (namely 'schizophrenia and other psychotic disorders', and 'cannabis use disorder') to that in healthy controls using the PET radiotracer 11C-APP311
次要结局
- Correlation of Synaptic density with cognition and EEG(One test day (one time point).)
研究者
Deepak C. D'Souza
Professor of Psychiatry
Yale University