Impact of Reduced Arterial Stiffness on Peripheral Vascular Function and Mobility
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 主要终点
- Blood Flow
研究概览
简要总结
The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.
详细描述
This project employed a placebo controlled, double-blind, crossover trial. Participants were randomized to oral L-citrulline (6 g/day) or placebo (maltodextrin) for 14 days, and switched to the other treatment for another 14 days after washout. Peripheral vascular function was assessed under conditions of rest, leg exercise, and cognitive engagement. Gait performance was assessed using clinical walking tests.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
盲法说明
Double-blind research study
入排标准
- 年龄范围
- 60 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •older adults
- •women and men
- •aged 60-79 yrs
- •must be able to swallow capsules
- •fully mobile without assistive walking devices
排除标准
- •have physician diagnosed cardiovascular, pulmonary, or metabolic disease
- •are current smokers
- •currently taking medications affecting cardiovascular function
- •have high blood pressure (>159/99 mmHG)
- •have high fasting blood glucose (>110 mg/dL)
- •are considered obese (body mass index ≥ 30 kg/m2)
- •have orthopaedic limitations that limit walking ability
- •have pacemaker or other metal objects in their body
研究组 & 干预措施
CitrullinePlacebo
Subjects allocated to the CitrullinePlacebo study arm received L-citrulline first, followed by placebo.
干预措施: Placebo (Other)
PlaceboCitrulline
Subjects allocated to the PlaceboCitrulline study arm received placebo first, followed by L-citrulline.
干预措施: Placebo (Other)
PlaceboCitrulline
Subjects allocated to the PlaceboCitrulline study arm received placebo first, followed by L-citrulline.
干预措施: L-citrulline (Dietary Supplement)
CitrullinePlacebo
Subjects allocated to the CitrullinePlacebo study arm received L-citrulline first, followed by placebo.
干预措施: L-citrulline (Dietary Supplement)
结局指标
主要结局
Blood Flow
时间窗: baseline and 2 weeks for L-citrulline and placebo
Femoral blood flow during leg exercise and carotid blood flow during mental activity measured using Doppler ultrasound. Blood-oxygen-level dependent contrast imaging of the brain using functional magnetic resonance imaging (fMRI) during cognitive functioning.
次要结局
- Gait Performance(baseline and 2 weeks for L-citrulline and placebo)
研究者
Joaquin U Gonzales, PhD
Associate Professor
Texas Tech University