The incidence and risk factors for cardiovascular complications after oncosurgeries: A retrospective analysis

Postoperative cardiac complicationsare major cause of morbidity and mortality in onco surgeries. Since malignancyis a  prothrombotic state the riskof  thrombotic events such as DVT(1),pulmonary embolisms and MI are high in these patients.Oncologic patientsare more prone for nutritional deficiency and cancer cachexia leading multipleelectrolyte imbalances.Age >75 yrs associated with increased risk of cardiaccomplications (2) Postoperative arrhythmias are frequent cause of morbiditywith atrial fibrillation and QT prolongation having specific relevance to theperi operative period.(3)

AIMTo estimate the incidence ofpostoperative cardiovascular complications following major cancer surgeries andto identify associated risk factors.

OBJECTIVES

â—     Primaryobjective **-**To find out theassociation with various risk factors and post op cardiac events.

â—     Secondaryobjective - To measure the incidence of electrolyte imbalances and association tocardiac events.

METHODS

â—     Study setting

Department ofAnaesthesiology, Regional Cancer Center, Thiruvananthapuram.

â—     Studypopulation

Inclusioncriteria:Allpostoperative patients above 18 yrs

Exclusion criteria:Age below 18 yrs

â—     Methodology

Study will beconducted over a period of one year by reviewing the records.Patients will be selected on basis of inclusion and exclusion criteria.

â—     Statisticalanalysis

The χ 2 testor Fisher’s exact test will be used to compare the distribution of categoricvariables, the Student t test will be used to compare continuous variables, andthe Kruskal-Wallis nonparametric test will be used for comparison of data thatdid not obey a normal distribution.

The confidenceintervals (CI) of the cumulative incidence of observed cardiac complicationswill be calculated using a binomial approach. The adjusted contribution of the different riskfactors will be estimated by Poisson regression.

REFERENCES

1.    Khushal A, Quinlan D, Alikhan R, GardnerJ, Bailey C, Cohen A. Thromboembolic disease in surgery formalignancy-rationale for prolonged thromboprophylaxis. Semin Thromb Hemost.2002 Dec;28(6):569-76. doi: 10.1055/s-2002-36701. PMID: 12536350.

2.    JoanPuig-Barberà, Soledad Márquez-Calderón, MiguelVila-Sánchez. Cardiac Complications of Major Elective Non-Cardiac Surgery:Incidence and Risk Factors.

3.    D. Sellers, C. Srinivas,G. Djaiani. Cardiovascular complications after non-cardiac surgery. Anaesthesia2018, 73 (Suppl. 1), 34–42.