Efficacy of Henagliflozin for Weight Loss in Obesity Without Diabetes: a Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 300
- 主要终点
- Weight change
研究概览
简要总结
This trial is conducted in China. The purpose of the 24-week trial is to investigate the efficacy of henagliflozin to induce body weight loss and the purpose of the extension is to evaluate the hypoglycemic effect of henagliflozin in obese subjects without diabetes.
Trial has the following two periods: 1) A 12-week randomized, double-blind, placebo-controlled, multi-center trial for evaluating the efficacy of henagliflozin to induce body weight loss; 2) A 12-week multicenter randomized controlled open-label trial for evaluating the hypoglycemic effect of henagliflozin followed by a 24-week extension period.
详细描述
Primary Hypothesis:
The 12-week henagliflozin taking could induce significantly higher weight loss in obese subjects without diabetes, compared to diet-exercise therapy.
Assessment time points:
Baseline: prior to taking henagliflozin or diet-exercise therapy V1: 4 weeks following the henagliflozin taking or diet-exercise therapy V2: 4 weeks following V1 V3: 4 weeks following V2
Specific Aims 1:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
盲法说明
Participants and care providers are all masked. Investigators randomly cluster the participants, and the actual mask of the participant is not available to care providers and the participants
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years old≤age≤65 years old, regardless of gender and race
- •Nondiabetic population: without hypoglycemic treatment, FPG<7.0 mmol/l, PPG<11.1 mmol/l, and HbA1c<6.5%
- •obesity: BMI≥28 kg/m2
- •Stable weight: weight change less than 5kg in the past 3 months
- •Ability to understand and sign the informed consent form
排除标准
- •Allergies to Henagliflozin or its formulations;
- •Participants have been definitely diagnosed with diabetes;
- •HbA1c≥6.5 % or FPG≥7.0 mmol/l, or PPG≥11.1 mmol/l;
- •Participants have used glucagon-like peptide-1 (GLP-1) receptor agonists, sodium glucose linked transporter-2 (SGLT-2) inhibitors, or other weight loss related drugs within the past 3 months;
- •History of bariatric surgery;
- •Untreated or uncontrolled hypothyroidism/hyperthyroidism;
- •High risk of urinary tract infection;
- •Obesity induced by other endocrinologic disorders (e.g. Cushing's Syndrome);
- •Diagnosis of congenital glucose-galactose malabsorption or familial renal glycosuria
- •Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥ 2.5 times the upper limit of the normal range (UNL); Total bilirubin (TBIL) ≥ 2.0 times the upper limit of the normal range;
- •estimated glomerular filtration rate (eGFR)<30 mL/min/1.73 m2 or end-stage kidney disease, or requiring dialysis;
- •History of major depressive disorder or other severe psychiatric disorders, e.g. schizophrenia, bipolar disorder within the last 2 years;
- •Uncontrolled treated/untreated hypertension (systolic blood pressure ≥160 mm Hg and/or diastolic blood pressure ≥100 mm Hg)
- •myocardial infarction, unstable angina, revascularization surgery, or cerebrovascular diseases within the past 3 months;
- •Cancer (past or present, except basal cell skin cancer or squamous cell skin cancer) or other severe diseases, which in the investigator's opinion could interfere with the results of the trial;
- •Females of child-bearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods (adequate contraceptive measures as required by local law or practice) within 24 months;
- •Participation in a clinical trial within the last 3 months prior to screening;
- •Previous history of gestational diabetes;
- •Previous history of eating disorders;
- •Current or history of treatment with medications that may cause significant weight gain, within 3 months prior to screening, including systemic corticosteroids (except for a short course of treatment, i.e. 7-10 days), tri-cyclic antidepressants, atypical antipsychotic and mood stabilizers (e.g. imipramine, amitriptyline, mirtazapine, paroxetine, phenelzine, chlorpromazine, thioridazine, clozapine, olanzapine, valproic acid and its derivatives, and lithium);
- •Diet attempts using herbal supplements or over-the-counter medications within 3 months before screening
- •Any lifetime history of a suicidal attempt or a history of any suicidal behavior in the last month prior to randomization;
- •Surgery scheduled for the trial duration period, except for minor surgical procedures, at the discretion of the investigator
- •Known or suspected abuse of alcohol or narcotics
- •Subjects from the same house hold participating in the trial
- •Other situations which were inappropriate to the trial, at the discretion of the investigator
研究组 & 干预措施
Control group
Placebo and diet-exercise therapy
干预措施: Placebo (Drug)
Intervention group
10mg of Henagliflozin and diet-exercise therapy
干预措施: Henagliflozin (Drug)
结局指标
主要结局
Weight change
时间窗: 3 months (12 weeks)
Proportion of weight change from baseline
次要结局
- Incident diabetes(1 month (4 weeks), 2 months (8 weeks), 3 months (12 weeks), 6 months (24 weeks), 9 months (36 weeks), 12 months (48 weeks))
- Proportion of ≥5% weight loss(3 months (12 weeks))